1. GPCR/G Protein
    Neuronal Signaling
  2. Somatostatin Receptor
  3. AGI-43192

AGI-43192 

Cat. No.: HY-145777 Purity: 99.53%
Handling Instructions

AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 is a potent, but limited brain-penetrant compound. AGI-43192 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease.

For research use only. We do not sell to patients.

AGI-43192 Chemical Structure

AGI-43192 Chemical Structure

CAS No. : 2377491-54-6

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 560 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1130 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 is a potent, but limited brain-penetrant compound. AGI-43192 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease[1].

Molecular Weight

484.86

Formula

C23H16ClF3N6O

CAS No.
SMILES

O=C1C(C2=CC=C(Cl)C=C2)=C3N=C(NCC(F)(F)F)N=CC3=CN1C4=CC5=CN(C)N=C5C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (171.86 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0625 mL 10.3123 mL 20.6245 mL
5 mM 0.4125 mL 2.0625 mL 4.1249 mL
10 mM 0.2062 mL 1.0312 mL 2.0625 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 8.33 mg/mL (17.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 8.33 mg/mL (17.18 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.53%

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× = ×
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Product Name:
AGI-43192
Cat. No.:
HY-145777
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