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FIDAS-5 

Cat. No.: HY-136144 Purity: 98.10%
Handling Instructions

FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities.

For research use only. We do not sell to patients.

FIDAS-5 Chemical Structure

FIDAS-5 Chemical Structure

CAS No. : 1391934-98-7

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Based on 1 publication(s) in Google Scholar

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Description

FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities[1].

IC50 & Target

IC50: 2.1 μM (Methionine S-adenosyltransferase 2A (MAT2A))[1]

In Vitro

FIDAS-5 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells[1].
FIDAS-5 (3 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-5 induces the expression of cell cycle inhibitor, p21WAF1/CIP1[1].
FIDAS-5 (3 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: LS174T colorectal cancer (CRC) cells
Concentration: 3 μM
Incubation Time: 7 days
Result: Significantly inhibited the proliferation of LS174T cells.
In Vivo

FIDAS-5 (20 mg/kg; oral gavage; daily; for two weeks; athymic nude mice) treatment significantly inhibits the growth of xenograft tumors, with minimal difference in body weight[1].
Mice are treated with FIDAS-5 (20 mg/kg) for 1 week. The liver SAM levels are significantly reduced[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 16 athymic nude mice injected with HT29 CRC cells[1]
Dosage: 20 mg/kg
Administration: Oral gavage; daily; for two weeks
Result: Significantly inhibited the growth of xenograft tumors.
Molecular Weight

261.72

Formula

C₁₅H₁₃ClFN

CAS No.

1391934-98-7

SMILES

CNC1=CC=C(/C=C/C2=C(F)C=CC=C2Cl)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (477.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8209 mL 19.1044 mL 38.2088 mL
5 mM 0.7642 mL 3.8209 mL 7.6418 mL
10 mM 0.3821 mL 1.9104 mL 3.8209 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

FIDAS-5FIDAS5FIDAS 5WntMAT2Aanti-cancerS-adenosylmethioninecolorectalSAMSAHc-MycCyclinD1p21WAF1/CIP1anti-proliferationInhibitorinhibitorinhibit

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Product Name:
FIDAS-5
Cat. No.:
HY-136144
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