2. Epigenetics Metabolic Enzyme/Protease
  3. Methionine Adenosyltransferase (MAT)
  4. MAT2A inhibitor 5

MAT2A inhibitor 5(compound 39) is an orally active, selectivity and blood-brain permeability inhibitor of MAT2A with the IC50 of 11 nM. MAT2A inhibitor 5 inhibits tumor cell growth in vivo.

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MAT2A inhibitor 5

MAT2A inhibitor 5 Chemical Structure

CAS No. : 2957874-18-7

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Description

MAT2A inhibitor 5(compound 39) is an orally active, selectivity and blood-brain permeability inhibitor of MAT2A with the IC50 of 11 nM. MAT2A inhibitor 5 inhibits tumor cell growth in vivo[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
258.8 nM
Compound: 39
Antiproliferative activity against MTAP-knock out human HCT-116 cells assessed as cell viability at incubated for 8 days by multifunctional microplate reader analysis
Antiproliferative activity against MTAP-knock out human HCT-116 cells assessed as cell viability at incubated for 8 days by multifunctional microplate reader analysis
[PMID: 38818879]
HCT-116 IC50
> 10000 nM
Compound: 39
Antiproliferative activity against wild type human HCT116 cells assessed as cell viability at incubated for 8 days by multifunctional microplate reader analysis
Antiproliferative activity against wild type human HCT116 cells assessed as cell viability at incubated for 8 days by multifunctional microplate reader analysis
[PMID: 38818879]
Molecular Weight

368.79

Formula

C19H14ClFN4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC(Cl)=C(C=C2C3=CN(N=C13)C)F)C4=CC=CN=C4C5CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 1.67 mg/mL (4.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7116 mL 13.5579 mL 27.1157 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7116 mL 13.5579 mL 27.1157 mL 67.7893 mL
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MAT2A inhibitor 5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAT2A inhibitor 52957874-18-7Methionine Adenosyltransferase (MAT)S-adenosylmethionine Synthetasexenograft MTAP-depleted modelInhibitorinhibitorinhibit

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