MAT2A inhibitor 6
MAT2A inhibitor 6 (Compound 3N-h) is a specific MAT2A inhibitor with oral activity and yellow fluorescence (IC50=26 nM), capable of visualizing MAT2A both in vitro and in vivo (λex = 430 nm, λem = 585 nm). MAT2A inhibitor 6 can induce apoptosis and has anticancer activity, which can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2447686-21-5
- Formula: C24H19F2N5O3
- Molecular Weight:463.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 26 nM (MAT2A)[1].
MAT2A inhibitor 6 (Compound 3N-h) (72 h) significantly inhibits the proliferation of HCT-116 (MTAP KO) cells, with an IC50 of 0.1 μM, and (1 μM; 24 h) induces apoptosis in these cells (43% of cells are in early or late apoptosis), but is almost non-toxic to wild-type HCT-116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2447686-21-5
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Molecular Weight 463.44
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Formula C24H19F2N5O3
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SMILES
O=C1C(C2=CC=C(OC(F)F)C=C2)=C3C(C=CC(OCC)=N3)=NN1C4=CC5=CN(C)N=C5C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAT2A inhibitor 6 Related Classifications
HY-159156 Related Classifications
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