MAT1A - methionine adenosyltransferase 1A Gene

Also Known as MAT; SAMS; MATA1; SAMS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4143

About MAT1A

Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:80,271,820-80,289,658 (from NCBI)

This gene has 4 transcripts (splice variants), 251 orthologues, 1 paralogue and is associated with 3 phenotypes. Restricted expression toward liver (RPKM 313.0).

Summary

This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]

MAT1A Products (1)

mRNA	Protein	Name
NM_000429.3	NP_000420.1	S-adenosylmethionine synthase isoform type-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables methionine adenosyltransferase activity	IDA IDA: Inferred from direct assay	10677294	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in S-adenosylmethionine biosynthetic process	IDA IDA: Inferred from direct assay	25075345	GOA
involved in S-adenosylmethionine biosynthetic process	IMP IMP: Inferred from mutant phenotype	10677294	GOA
involved in methionine catabolic process	IMP IMP: Inferred from mutant phenotype	10677294	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	23425511	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of methionine adenosyltransferase complex	IPI IPI: Inferred from physical interaction	25075345	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAT1A Protein Structure

S-AdoMet_synt_N

S-AdoMet_synt_M

S-AdoMet_synt_C

0
100
200
300
395 a.a.

Protein Preferred Names	Protein Names
S-adenosylmethionine synthase isoform type-1	MAT 1

MAT1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAT1A	Q00266	MAT2A	Homo sapiens	P31153	Anti Tag CoIP	33961781
Intra	MAT1A	Q00266	MAT2A	Homo sapiens	P31153	Y2H Prey Pooling	32296183
Intra	MAT1A	Q00266	MAT2A	Homo sapiens	P31153	Anti Tag CoIP	28514442
Intra	MAT1A	Q00266	MAT2A	Homo sapiens	P31153	Y2H Array	32296183
Intra	MAT1A	Q00266	MAT1A	Homo sapiens	Q00266	Y2H Array	32296183
Intra	MAT1A	Q00266	MAT2B	Homo sapiens	Q9NZL9-2	Anti Tag CoIP	28514442
Intra	MAT1A	Q00266	MAT1A	Homo sapiens	Q00266	Y2H Prey Pooling	32296183
Intra	MAT1A	Q00266	ASPSCR1	Homo sapiens	Q9BZE9-2	Anti Tag CoIP	28514442
Intra	MAT1A	Q00266	MAT2B	Homo sapiens	Q9NZL9	Anti Tag CoIP	33961781
Intra	MAT1A	Q00266	ASPSCR1	Homo sapiens	Q9BZE9	Anti Tag CoIP	33961781
Intra	MAT1A	Q00266	MAT1A	Homo sapiens	Q00266	Validated Y2H	32296183
Intra	MAT1A	Q00266	MAT1A	Homo sapiens	Q00266	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

MAT1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83454	MAT1A Antibody (YA3199)	WB, IP	Human, Mouse, Rat
HY-P83454A	MAT1A Antibody (YA3199)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Methionine Adenosyltransferase I/Iii Deficiency	Mat I/Iii Deficiency Mat Deficiency Methionine Adenosyltransferase Deficiency, Autosomal Recessive Hypermethioninemia, Persistent, Autosomal Dominant, Due To Methionine Adenosyltransferase I/Iii Deficiency Methionine Adenosyltransferase Deficiency Hypermethioninemia, Isolated Persistent Brain Demyelination Due To Methionine Adenosyltransferase Deficiency MATD Isolated Persistent Hypermethioninemia Hepatic Methionine Adenosyltransferase Deficiency Deficiency Of Acetyl-Coa Acetyltransferase
Hypermethioninemia	Hepatic Methionine Adenosyltransferase Deficiency Deficiency Of Methionine Adenosyltransferase Glycine N-Methyltransferase Deficiency Met S-Adenosylhomocysteine Hydrolase Deficiency Gnmt Deficiency Mat Deficiency Methionine Adenosyltransferase Deficiency Methioninemia Deficiency Of Acetyl-Coa Acetyltransferase
Methionine Adenosyltransferase Deficiency	Mat Deficiency Hepatic Methionine Adenosyltransferase Deficiency Deficiency Of Acetyl-Coa Acetyltransferase
Glycine N-Methyltransferase Deficiency	GNMT DEFICIENCY Hypermethioninemia Due To Glycine N-Methyltransferase Deficiency Hypermethioninemia Due To Gnmt Deficiency Hypermethioninemia Hepatic Methionine Adenosyltransferase Deficiency
Alpha-Methylacetoacetic Aciduria	Beta-Ketothiolase Deficiency 3-Ketothiolase Deficiency 3-Oxothiolase Deficiency Mitochondrial Acetoacetyl-Coa Thiolase Deficiency Alpha-Methylacetoaceticaciduria Mat Deficiency T2 Deficiency 2-Methyl-3-Hydroxybutyricacidemia Beta Ketothiolase Deficiency Pseudo-Zellweger Syndrome 2-Methyl-3-Hydroxybutyric Acidemia 3-Ktd Deficiency Peroxisomal Thiolase Deficiency 2-Methylacetoacetyl-Coenzyme A Thiolase Deficiency 3-Alpha-Oxothiolase Deficiency Methylacetoacetyl-Coenzyme A Thiolase Deficiency Mitochondrial 2-Methylacetoacetyl-Coa Thiolase Deficiency - Potassium Stimulated Β-Ketothiolase Deficiency Alpha Methylacetoacetic Aciduria Alpha-Methyl-Acetoacetyl-Coa Thiolase Deficiency Mitochondrial Acetoacetyl-Coenzyme A Thiolase Deficiency 3KTD Aciduria, Alpha-Methylacetoacetic Deficiency Of Acetyl-Coa Acetyltransferase Deficiency Of Acetyl-Coa Acyltransferase Hepatic Methionine Adenosyltransferase Deficiency Bifunctional Peroxisomal Enzyme Deficiency
Homocystinuria	Cystathionine Beta Synthase Deficiency Homocysteinemia Cbs Deficiency Cystathionine Synthase Deficiency Cystathionine Beta-Synthase Deficiency Disease
Liver Cirrhosis	Cirrhosis Cirrhosis Of Liver CIRRH Cryptogenic Cirrhosis Cirrhosis, Cryptogenic Cirrhosis Nos
Intestinal Disaccharidase Deficiency	Disaccharidase Deficiency
Clear Cell Acanthoma	Acanthoma Pale Acanthoma Acanthoma, Clear Cell
Mend Syndrome	Male Ebp Disorder With Neurological Defects MEND Male Ebp Disorder With Neurologic Defects
Tyrosinemia, Type I	Tyrosinemia Type I Hepatorenal Tyrosinemia Fumarylacetoacetase Deficiency Fah Deficiency TYRSN1 Fumarylacetoacetate Hydrolase Deficiency Tyrosinemia Type 1 Tyrosinemia 1 Fumarylacetoacetase
Histidinemia	Histidine Ammonia-Lyase Deficiency Hal Deficiency Histidase Deficiency His Deficiency Histidinuria Hyperhistidinemia HISTID Histidinuria Renal Tubular Defect
Histidine Metabolism Disease	Disturbances Of Histidine Metabolism Disorder Of Histidine Metabolism Disturbance Of Histidine Metabolism
Hyperprolinemia, Type I	Proline Oxidase Deficiency Hyperprolinemia Type 1 HYRPRO1 Hpi Hyperprolinemia Type I Hyperprolinemia 1 Proline Dehydrogenase Deficiency
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Alkaptonuria	Homogentisic Acid Oxidase Deficiency Alcaptonuria AKU Deficiency Of Homogentisicase Homogentisate 1,2-Dioxygenase Deficiency Alkaptonuric Ochronosis Homogentisic Acidura Ochronosis, Hereditary Hereditary Ochronosis Ochronosis Homogentisicaciduria Deficiency Of Homogentisate Oxygenase
Amino Acid Metabolic Disorder	Amino Acid Metabolism, Inborn Errors Inborn Errors Of Amino Acid Metabolism Disorder Of Amino Acid Metabolism Amino Acid Metabolism Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116688	2-Hydroxy-4-(methylthio)butyric acid		88.0%	Unkown
HY-162353	AZ'9567		99.19%	Unkown
HY-RS08166	MAT1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20986	Mat1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27503	Mat1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAT1A	VGNC	VGNC:31261
Macaca mulatta	MAT1A	VGNC	VGNC:74663
Canis familiaris	MAT1A	VGNC	VGNC:43037
Felis catus	MAT1A	VGNC	VGNC:68192
Rattus norvegicus	MAT1A	RGD	RGD:3050
Mus musculus	MAT1A	MGD	MGI:88017
Others	MAT1A	NCBI