MAT2B - methionine adenosyltransferase 2B Gene

Also Known as TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27430

About MAT2B

Cytogenetic location: 5q34 Genomic coordinates (GRCh38): 5:163,503,064-163,519,354 (from NCBI)

This gene has 33 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in lymph node (RPKM 45.7), thyroid (RPKM 43.7) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

MAT2B Products (2)

mRNA Protein Name
NM_013283.5 NP_037415.1 methionine adenosyltransferase 2 subunit beta isoform 1
NM_182796.2 NP_877725.1 methionine adenosyltransferase 2 subunit beta isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
10644686 GOA
enables methionine adenosyltransferase regulator activity IDA
IDA: Inferred from direct assay
10644686 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25075345 GOA
Biological Process GO Annotation Evidence References Source
involved in S-adenosylmethionine biosynthetic process IDA
IDA: Inferred from direct assay
10644686 GOA
Cellular Component GO Annotation Evidence References Source
part of methionine adenosyltransferase complex IDA
IDA: Inferred from direct assay
10644686 GOA
part of methionine adenosyltransferase complex IPI
IPI: Inferred from physical interaction
25075345 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAT2B Protein Structure

RmlD_sub_bind

RmlD_sub_bind: RmlD substrate binding domain (30 - 322)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

methionine adenosyltransferase 2 subunit beta

  • MAT II beta

MAT2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAT2B Q9NZL9 MAT2A Homo sapiens P31153
Anti Tag CoIP
33961781
Intra
MAT2B Q9NZL9 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
MAT2B Q9NZL9 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
MAT2B Q9NZL9 PLA2G6 Homo sapiens O60733
Y2H Prey Pooling
32296183
Intra
MAT2B Q9NZL9 PLA2G6 Homo sapiens O60733
Y2H Array
32296183
Cross
MAT2B Q9NZL9 P0DTD1-PRO_0000449627 SARS-CoV-2 P0DTD1-PRO_0000449627
Y2H Array
36217030
Intra
MAT2B Q9NZL9 KPNA3 Homo sapiens O00505
Y2H Array
32296183
Intra
MAT2B Q9NZL9 KPNA3 Homo sapiens O00505
Y2H Prey Pooling
25416956
Intra
MAT2B Q9NZL9 KPNA3 Homo sapiens O00505
Y2H Prey Pooling
32296183
Intra
MAT2B Q9NZL9 RABEP1 Homo sapiens Q15276
Y2H Array
32296183
Intra
MAT2B Q9NZL9 RABEP1 Homo sapiens Q15276
Y2H Prey Pooling
32296183
Intra
MAT2B Q9NZL9 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
MAT2B Q9NZL9 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypermethioninemia

  • Hepatic Methionine Adenosyltransferase Deficiency

  • Deficiency Of Methionine Adenosyltransferase

  • Glycine N-Methyltransferase Deficiency

  • Met

  • S-Adenosylhomocysteine Hydrolase Deficiency

  • Gnmt Deficiency

  • Mat Deficiency

  • Methionine Adenosyltransferase Deficiency

  • Methioninemia

  • Deficiency Of Acetyl-Coa Acetyltransferase
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08168 MAT2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20987 Mat2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27504 Mat2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181978 GIT1-IN-1 / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAT2B MGD MGI:1913667
Canis familiaris MAT2B VGNC VGNC:43038
Rattus norvegicus MAT2B RGD RGD:1593534
Felis catus MAT2B VGNC VGNC:102251
Macaca mulatta MAT2B VGNC VGNC:84437
Bos taurus MAT2B VGNC VGNC:31262
Others MAT2B NCBI