2. Epigenetics Metabolic Enzyme/Protease
  3. Methionine Adenosyltransferase (MAT)
  4. AGI-25696

AGI-25696 is an orally active ethionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 97 nM. AGI-25696 reduces intracellular SAM levels in cancer cells. AGI-25696 inhibits tumor growth in mice bearing subcutaneous KP4 MTAP-null pancreatic xenografts. AGI-25696 can be used for the research of mtap-deleted pancreatic cancer.

For research use only. We do not sell to patients.

AGI-25696

AGI-25696 Chemical Structure

CAS No. : 2201065-84-9

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AGI-25696 Related Antibodies

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Description

AGI-25696 is an orally active ethionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 97 nM. AGI-25696 reduces intracellular SAM levels in cancer cells. AGI-25696 inhibits tumor growth in mice bearing subcutaneous KP4 MTAP-null pancreatic xenografts. AGI-25696 can be used for the research of mtap-deleted pancreatic cancer[1].

IC50 & Target[1]

MAT2A

97 nM (IC50)

In Vitro

AGI-25696 potently inhibits purified recombinant MAT2A homodimer with an IC50 of 97 nM[1].
AGI-25696 (72 h) dose-dependently reduces intracellular SAM levels in HCT116 MTAP-null cells with an IC50 of 150 nM and 84% maximal inhibition after 72 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AGI-25696 Related Antibodies
In Vivo

AGI-25696 (300 mg/kg; p.o.; once daily; 33 days) achieves a tumor growth inhibition of 67.8% in mice bearing subcutaneous KP4 MTAP-null pancreatic xenografts, with no observed body weight loss[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice bearing subcutaneous KP4 MTAP-null
xenografts[1]
Dosage: 300 mg/kg
Administration: p.o.; once daily; 33 days
Result: Achieved a tumor growth inhibition (TGI) of 67.8% relative to vehicle-treated controls.
Caused no adverse effects on mouse body weight during the 33-day study.
Molecular Weight

428.48

Formula

C28H20N4O
CAS No.
SMILES

O=C1C(C2=CC3=C(N=CC=C3)C=C2)=C(C)NC4=C(C(C5=CC=CC=C5)=NN14)C6=CC=CC=C6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AGI-25696 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGI-256962201065-84-9AGI25696AGI 25696Methionine Adenosyltransferase (MAT)S-adenosylmethionine Synthetasemtap-deleted pancreatic cancerhuman liver microsomesMAT2Apancreatic KP4 MTAP-null xenograft tumorsHCT116 MTAP-null cellsSAMMTAP-null cancer cellsInhibitorinhibitorinhibit

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