2201065-84-9
2201065-84-9
Chemical Structure
AGI-25696
- CAS No.: 2201065-84-9
- Formula:C28H20N4O
- Molecular Weight:428.48
InChIKey: ZMZOMWGRJGQLDW-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC3=C(N=CC=C3)C=C2)=C(C)NC4=C(C(C5=CC=CC=C5)=NN14)C6=CC=CC=C6
Biological Activity: AGI-25696 is an orally active ethionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 97 nM. AGI-25696 reduces intracellular SAM levels in cancer cells. AGI-25696 inhibits tumor growth in mice bearing subcutaneous KP4 MTAP-null pancreatic xenografts. AGI-25696 can be used for the research of mtap-deleted pancreatic cancer[1].
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AGI-25696 | AGI-25696 is an orally active ethionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 97 nM. AGI-25696 reduces intracellular SAM levels in cancer cells. AGI-25696 inhibits tumor growth in mice bearing subcutaneous KP4 MTAP-null pancreatic xenografts. AGI-25696 can be used for the research of mtap-deleted pancreatic cancer. | |||||||||||||||||||||
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