MCULE-3064932370
MCULE-3064932370 is a covalent and allosteric SUMO E1 (heterodimer of Aos1 and Uba2) inhibitor with IC50 values ranging from 16.66 μM to 2.96 μM. MCULE-3064932370 inhibits SUMOylation of Uba2. MCULE-3064932370 has anti-cancer activity against breast cancer.
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- CAS 番号: 315698-78-3
- 分子式: C18H12N2O3S2
- 分子量:368.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
MCULE-3064932370 (0-100 μM; 0-1.5 h pre-incubation) time-dependently and concentration-dependently inhibits purified human SUMO E1 (Aos1/Uba2 complex) activity, with IC50 values ranging from 16.66 ± 9.55 μM to 2.96 ± 1.61 μM over 0 to 1.5 hours of pre-incubation[1].
MCULE-3064932370 (0.1-100 μM; 24-48 h) concentration-dependently inhibits T47D breast cancer cell proliferation, with EC50 values of 20.79 ± 3.26 μM (24 h) and 10.40 ± 4.58 μM (48 h)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human T47D breast cancer cells
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Concentration:12.5 μM, 25 μM
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Incubation Time:24 h
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Result:Reduced relative cell migration to 0.54 (12.5 μM) and 0.32 (25 μM) of vehicle control.
化学情報
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CAS 番号 315698-78-3
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分子量 368.43
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分子式 C18H12N2O3S2
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SMILES
O=C(C(SC#N)=C/1)C2=CC=CC=C2C1=N\S(=O)(C3=CC=C(C)C=C3)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MCULE-3064932370 関連分類
HY-181772 関連分類
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