2. Epigenetics Metabolic Enzyme/Protease
  3. Methionine Adenosyltransferase (MAT)
  4. MAT2A ligand 1

MAT2A ligand 1 is a MAT2A ligand inhibitor (IC50=29.5 nM) and PET tracer that crosses the blood-brain barrier. MAT2A ligand 1 enables non-invasive imaging of MAT2A-expressing tumors, with rapid tumor uptake equilibrium, a high tumor-to-muscle ratio, and specific tumor-binding properties. MAT2A ligand 1 is applicable to research related to non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, gastric cancer, glioblastoma, pancreatic adenocarcinoma, urothelial carcinoma, breast cancer, and prostate cancer.

For research use only. We do not sell to patients.

MAT2A ligand 1

MAT2A ligand 1 Chemical Structure

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MAT2A ligand 1 Related Antibodies

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Description

MAT2A ligand 1 is a MAT2A ligand inhibitor (IC50=29.5 nM) and PET tracer that crosses the blood-brain barrier. MAT2A ligand 1 enables non-invasive imaging of MAT2A-expressing tumors, with rapid tumor uptake equilibrium, a high tumor-to-muscle ratio, and specific tumor-binding properties. MAT2A ligand 1 is applicable to research related to non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, gastric cancer, glioblastoma, pancreatic adenocarcinoma, urothelial carcinoma, breast cancer, and prostate cancer[1].

In Vitro

[18F]MAT2A ligand 1 ([18F]1d) (1 μCi/mL; 5-120 min) is specifically taken up by H1975 cells via binding to MAT2A, with an internalization rate of 46%, and shows a relatively fast efflux rate (the efflux rate reaches 70% at 120 min)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAT2A ligand 1 Related Antibodies
In Vivo

18F]1d (3.7-7.4 MBq/100 μL; intravenous tail injection) achieves consistent tumor uptake across multiple solid tumor xenograft models with MAT2A expression, validating its broad utility for MAT2A-targeted PET imaging despite no direct correlation between uptake levels and reported MAT2A expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Multiple solid tumors model in BALB/c nude (female, 6-8 weeks old, 12-16 g, subcutaneous xenograft of A549/PC-3/22RV1/MCF-7/MDA-MB-231/DU145 cells)[1]
Dosage: 3.7-7.4 MBq/100 μL
Administration: Intravenous tail injection;22Rv1, A549, DU145, MCF-7, MDA-MB-231, and PC-3 subcutaneous tumor at 1 h and 2 h post-treatment; measured at 60 and 120 min
Result: Achieved tumor uptake values of 4.06 ± 0.37 %ID/g (22RV1), 3.86 ± 0.42 %ID/g (A549), 4.11 ± 0.36 %ID/g (DU145), 4.56 ± 0.29 %ID/g (MCF-7), 3.16 ± 0.45 %ID/g (MDA-MB-231), and 4.1 ± 0.11 %ID/g (PC-3) at 1 hour post-injection.
Showed generally comparable tumor-to-muscle ratios across all six models, with only MDA-MB-231 having slightly lower tumor uptake.
Showed no positive correlation between tumor uptake and MAT2A expression levels across the models.
Molecular Weight

376.81

Formula

C18H18ClFN4O2
SMILES

O=C1N(C2=C(C(N(C)CCOCCF)=N1)C=CC(Cl)=C2)C3=CC=NC=C3
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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MAT2A ligand 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAT2A ligand 1Methionine Adenosyltransferase (MAT)S-adenosylmethionine SynthetaseTrp274hepatocellular carcinomacolorectal cancerPhe333glioblastomaH1975 cellsArg313MAT2APhe18non-small cell lung cancerInhibitorinhibitorinhibit

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