2. Epigenetics
    Metabolic Enzyme/Protease
  3. Methionine Adenosyltransferase (MAT)
  4. MAT2A inhibitor 3

MAT2A inhibitor 3 

Cat. No.: HY-139139 Purity: 99.81%
COA Handling Instructions

MAT2A inhibitor 3 is a methionine adenosyltransferase 2A (MAT2A) inhibitor extracted from patent WO2020123395A1, compound 24, has an IC50 of <200 nM. MAT2A inhibitor 3 can be used for the research of cancers.

For research use only. We do not sell to patients.

MAT2A inhibitor 3 Chemical Structure

MAT2A inhibitor 3 Chemical Structure

CAS No. : 2439271-82-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 330 In-stock
Solid
5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
100 mg USD 2250 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

MAT2A inhibitor 3 is a methionine adenosyltransferase 2A (MAT2A) inhibitor extracted from patent WO2020123395A1, compound 24, has an IC50 of <200 nM. MAT2A inhibitor 3 can be used for the research of cancers[1].

IC50 & Target

IC50: <200 nM (MAT2A)[1]
In Vitro

MAT2A inhibitor 3 is a potent methionine adenosyltransferase 2A inhibitor, with an IC50 of <200 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

299.75

Appearance

Solid

Formula

C16H14ClN3O
CAS No.
SMILES

O=C1N(C2=CC=CC=C2)C3=C(C=CC(Cl)=C3)C(N(C)C)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (166.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3361 mL 16.6806 mL 33.3611 mL
5 mM 0.6672 mL 3.3361 mL 6.6722 mL
10 mM 0.3336 mL 1.6681 mL 3.3361 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.34 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.34 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.81%

COA (253 KB) HNMR (240 KB) LCMS (268 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MAT2A inhibitor 32439271-82-4Methionine Adenosyltransferase (MAT)S-adenosylmethionine SynthetasemethionineadenosyltransferaseMAT2AcancerInhibitorinhibitorinhibit

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