1. Stem Cell/Wnt
  2. Wnt
  3. FIDAS-3

FIDAS-3 

Cat. No.: HY-136145
Handling Instructions

FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities.

For research use only. We do not sell to patients.

FIDAS-3 Chemical Structure

FIDAS-3 Chemical Structure

CAS No. : 1266684-01-8

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Description

FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].

IC50 & Target

IC50: 4.9 μM (Methionine S-adenosyltransferase 2A (MAT2A))[1]

In Vitro

FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells[1].
FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1[1].
FIDAS-3 (10 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells[1].

Cell Viability Assay[1]

Cell Line: LS174T colorectal cancer (CRC) cells
Concentration: 3 μM
Incubation Time: 7 days
Result: Significantly inhibited the proliferation of LS174T cells.
In Vivo

FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors[2].

Animal Model: C57BL/6J athymic nude mice (6-8 week) injected with LS174 cells[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; daily; for one months
Result: Significantly inhibited the growth of xenograft tumors.
Molecular Weight

259.29

Formula

C₁₆H₁₅F₂N

CAS No.

1266684-01-8

SMILES

CN(C)C1=CC=C(/C=C/C2=C(F)C=CC=C2F)C=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FIDAS-3FIDAS3FIDAS 3WntMAT2Aanti-cancerS-adenosylmethionineSAMSAHc-MycCyclinD1anti-proliferationβ-cateninInhibitorinhibitorinhibit

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FIDAS-3
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HY-136145
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