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SKL2001

62 Cited Publications
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Based on 62 publication(s) in Google Scholar

SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.

For research use only. We do not sell to patients.

  • Purity: 99.66%
  • CAS No.: 909089-13-0
  • Formula: C14H14N4O3
  • Molecular Weight:286.29
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • SKL2001 Chemical Structure
    SKL2001 Chemical Structure
  • Experimental Validation Results for SKL2001
  • Experimental Validation Results for SKL2001
  • Experimental Validation Results for SKL2001
  • Experimental Validation Results for SKL2001
  • Experimental Validation Results for SKL2001
  • Experimental Validation Results for SKL2001
CAS No.: 909089-13-0
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[email protected] [email protected]
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  • SKL2001 Chemical Structure
    SKL2001 Chemical Structure
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  • 1/16

    SKL2001 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Apr 19:S2090-1232(25)00273-5. [Abstract]

    Customer Validation
     Wnt/β-catenin activator SKL2001 (40 μM; 3 days) counteracted the promoting effect of AS-II on the Wnt/β-catenin signaling pathway in MO3.13 cells.

  • 1/16

    SKL2001 purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2025 Aug 13:8:0828. [Abstract]

    Customer Validation
     Schematic of experimental treatment of GL261-luc orthotopic model. Mice (n = 8) were treated with DMSO, ISP-I (50 mg/kg), SKL2001 (10 mg/kg), XAV939 (10 mg/kg), ISP-I (50 mg/kg) + SKL2001 (10 mg/kg), or ISP-I (50 mg/kg) + XAV939 (10 mg/kg) daily via oral gavage for 21 days. Assessment of tumor growth in each group was qualified by bioluminescence imaging.

  • 1/16

    SKL2001 purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2025 Aug 13:8:0828. [Abstract]

    Customer Validation
     Schematic of experimental treatment of GL261-luc orthotopic model. Mice (n = 8) were treated with DMSO, ISP-I (50 mg/kg), SKL2001 (10 mg/kg), XAV939 (10 mg/kg), ISP-I (50 mg/kg) + SKL2001 (10 mg/kg), or ISP-I (50 mg/kg) + XAV939 (10 mg/kg) daily via oral gavage for 21 days. Representative HE staining images of mouse cerebral tissues from each group, depicting tumor volumes.

  • 1/16

    SKL2001 purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2025 Aug 13:8:0828. [Abstract]

    Customer Validation
     Schematic of experimental treatment of GL261-luc orthotopic model. Mice (n = 8) were treated with DMSO, ISP-I (50 mg/kg), SKL2001 (10 mg/kg), XAV939 (10 mg/kg), ISP-I (50 mg/kg) + SKL2001 (10 mg/kg), or ISP-I (50 mg/kg) + XAV939 (10 mg/kg) daily via oral gavage for 21 days. The wet weight of collected tumors from each group was measured.

  • 1/16

    SKL2001 purchased from MedChemExpress. Usage Cited in: J Adv Res. 2022 Sep:40:197-206. [Abstract]

    Customer Validation
     Western blot and averaged data showing the protein levels of profibrogenic proteins Col1 and α-SMA in TGF-β1-stimulated PAFs with/without FABP5 knockdown treated with/without Wnt/β-catenin pathway agonist SKL2001 (20 μM; 24 h) were presented.

  • 1/16

    SKL2001 purchased from MedChemExpress. Usage Cited in: Mol Ther Nucleic Acids. 2020 Jun 27;21:577-591. [Abstract]

    Customer Validation
     Western blotting confirmed that β-catenin signaling is activated after GC cells are cultured with SKL2001 (40 μM), accompanied by the enhanced expression of the downstream molecules Cyclin D1, c-Myc, and nuclear β-catenin in BGC-823 cells.

  • SKL2001