1266684-01-8
1266684-01-8
Chemical Structure
FIDAS-3
- CAS No.: 1266684-01-8
- Formula:C16H15F2N
- Molecular Weight:259.29
IUPAC Name: (E)-4-(2,6-difluorostyryl)-N,N-dimethylaniline
InChIKey: YBJDCOLXJYDHOM-DHZHZOJOSA-N
SMILES: CN(C)C1=CC=C(/C=C/C2=C(F)C=CC=C2F)C=C1
Biological Activity: FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FIDAS-3 | 99.40% | FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. | ||||||||||||||||||||
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References
- [1]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803. [Content Brief]
- [2]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. J Med Chem. 2011 Mar 10;54(5):1288-97. [Content Brief]
Keywords
