1. Stem Cell/Wnt
  2. Wnt
  3. HLY78

HLY78 

Cat. No.: HY-122816 Purity: 98.38%
Handling Instructions

HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction.

For research use only. We do not sell to patients.

HLY78 Chemical Structure

HLY78 Chemical Structure

CAS No. : 854847-61-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 176 In-stock
Estimated Time of Arrival: December 31
5 mg USD 160 In-stock
Estimated Time of Arrival: December 31
10 mg USD 270 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    HLY78 purchased from MCE. Usage Cited in: Neurosci Bull. 2020 Oct;36(10):1171-1181.

    Effects of HLY78 on neuronal apoptosis at 24 h after SAH. Representative Western blot bands of Bcl-2, Bax, and cleaved caspase.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1].

    IC50 & Target

    Wnt/β-catenin[1]

    Molecular Weight

    267.32

    Formula

    C₁₇H₁₇NO₂

    CAS No.
    SMILES

    CCC1=CC=CC2=C1N(CC3=CC4=C(C=C32)OCO4)C

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 26 mg/mL (97.26 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.7408 mL 18.7042 mL 37.4083 mL
    5 mM 0.7482 mL 3.7408 mL 7.4817 mL
    10 mM 0.3741 mL 1.8704 mL 3.7408 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (7.78 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 98.38%

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    Keywords:

    HLY78HLY 78HLY-78WntInhibitorinhibitorinhibit

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    Product Name:
    HLY78
    Cat. No.:
    HY-122816
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