2. Stem Cell/Wnt
  3. Wnt
  4. NSC668036

NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 µM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction.

For research use only. We do not sell to patients.

NSC668036 Chemical Structure

NSC668036 Chemical Structure

CAS No. : 144678-63-7

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Based on 1 publication(s) in Google Scholar

NSC668036 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE NSC668036

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  • References

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Description

NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 µM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction[1].

In Vitro

In Xenopus, NSC668036 inhibiteds the signaling induced by Wnt3A[1].
NSC668036 (10 μM) suppresses β-catenin-driven gene transcription and abolished TGF-β1-induced migration, expression of collagen I and α-smooth muscle actin (α-SMA) in fibroblasts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC668036 Related Antibodies
In Vivo

In Bleomycin-induced pulmonary fibrosis murine model, NSC668036 (5 mg/kg) significantly suppresses accumulation of collagen I, α-SMA, and TGF-β1 but increased the expression of CK19, Occludin and E-cadherin that can inhibit pulmonary fibrogenesis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

460.52

Formula

C21H36N2O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C(OC(C(C)C)C(NC(C)C(OC(C(C)C)C(O)=O)=O)=O)=O)NC(OC(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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NSC668036 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC668036144678-63-7NSC 668036NSC-668036WntDishevelledPDZFrizzledWnt signalingInhibitorinhibitorinhibit

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