2. Stem Cell/Wnt
  3. Wnt
  4. KY02111

KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration.

For research use only. We do not sell to patients.

KY02111 Chemical Structure

KY02111 Chemical Structure

CAS No. : 1118807-13-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 49 In-stock
Solution
10 mM * 1 mL in DMSO USD 49 In-stock
Solid
5 mg USD 45 In-stock
10 mg USD 72 In-stock
50 mg USD 288 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 5 publication(s) in Google Scholar

KY02111 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration[1].

In Vitro

KY02111 promotes differentiation by inhibiting WNT signaling in hPSCs[1].
KY02111 induces cardiomyocytes expressed the cardiac markers, αMHC, NKH2.5, and HCN4[1].
KY02111 (1-10 μM; 12 hours, 24 hours) reduces WNT signaling in both IMR90-1 cells and HEK293 cells in a dose-dependent manner[1].
KY02111 treatment with WNT signaling modulators produces robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KY02111 Related Antibodies
Molecular Weight

376.86

Formula

C18H17ClN2O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC2=CC=C(Cl)C=C2S1)CCC3=CC=C(OC)C(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (88.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6535 mL 13.2675 mL 26.5351 mL
5 mM 0.5307 mL 2.6535 mL 5.3070 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6535 mL 13.2675 mL 26.5351 mL 66.3376 mL
5 mM 0.5307 mL 2.6535 mL 5.3070 mL 13.2675 mL
10 mM 0.2654 mL 1.3268 mL 2.6535 mL 6.6338 mL
15 mM 0.1769 mL 0.8845 mL 1.7690 mL 4.4225 mL
20 mM 0.1327 mL 0.6634 mL 1.3268 mL 3.3169 mL
25 mM 0.1061 mL 0.5307 mL 1.0614 mL 2.6535 mL
30 mM 0.0885 mL 0.4423 mL 0.8845 mL 2.2113 mL
40 mM 0.0663 mL 0.3317 mL 0.6634 mL 1.6584 mL
50 mM 0.0531 mL 0.2654 mL 0.5307 mL 1.3268 mL
60 mM 0.0442 mL 0.2211 mL 0.4423 mL 1.1056 mL
80 mM 0.0332 mL 0.1658 mL 0.3317 mL 0.8292 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

KY02111 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KY021111118807-13-8KY 02111KY-02111Wntcardiacdifferentiationof humanpluripotentstemcellscardiomyocyteregenerationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
KY02111
Cat. No.:
HY-13815
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.