1. Stem Cell/Wnt
  2. Wnt
  3. KY02111

KY02111 

Cat. No.: HY-13815 Purity: 99.90%
Handling Instructions

KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration.

For research use only. We do not sell to patients.

KY02111 Chemical Structure

KY02111 Chemical Structure

CAS No. : 1118807-13-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 288 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration[1].

In Vitro

KY02111 promotes differentiation by inhibiting WNT signaling in hPSCs[1].
KY02111 induces cardiomyocytes expressed the cardiac markers, αMHC, NKH2.5, and HCN4[1].
KY02111 (1-10 μM; 12 hours, 24 hours) reduces WNT signaling in both IMR90-1 cells and HEK293 cells in a dose-dependent manner[1].
KY02111 treatment with WNT signaling modulators produces robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

376.86

Formula

C₁₈H₁₇ClN₂O₃S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (88.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6535 mL 13.2675 mL 26.5351 mL
5 mM 0.5307 mL 2.6535 mL 5.3070 mL
10 mM 0.2654 mL 1.3268 mL 2.6535 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
KY02111
Cat. No.:
HY-13815
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