2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TGF-beta Superfamily
  5. Activin/Inhibins
  6. Activin A

Activin A

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Activin A, a multifunctional cytokine, is a member of TGF-β superfamily. Activin A first binds to the type II activin receptors (ActIIRA or ActRIIB) on the member surface, and then recruits and phosphorylates type I activin receptors (ActRI). Activin A primarily signal through SMAD2/3 proteins to regulate a variety of functions, including inflammation, fibrosis, and tumorigenesis. Activin is a member of transforming growth factor-β (TGF-β) superfamily consisting of two inhibin β subunits linked by disulfide bonds. Activin A is expressed widely in various tissues and cells with strong bioactivities and is the mostly studied activin[1].
The sequence of amino acids in Activin A proteins from different species is very stable, which leads to the conclusion that in the process of evolution, Activin A has been only slightly altered, and that both in humans and in animals, its function is similar.
Activin exists in three basic molecular forms composed of two inhibin β subunits: activin A (βAβA), activin B (βBβB), and activin AB (βAβB). Activin A binds with high affinity to activin type II receptors, which recruit type I receptors and are necessary for the activation of Smad2/3 signaling. The phosphorylated ActRI activates Smad2 and Smad3, which form a complex with Smad4 to translocate to the nucleus. Activin and TGF-β share the same signaling pathway at the level of Smad2/3/4. Activin A exerts a variety of biological functions including regulation of hematopoietic cell proliferation, neuron differentiation, pituitary hormone secretion, and tissue repair. It is also involved in the process of many diseases, for example, inflammation, fibrosis and tumorigenesis[1][2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70311
    Activin A Protein, Human/Mouse/Rat (HEK293)

    rHuActivin A; Inhibin beta A chain; INHBA; Activin A

    		Human HEK293
    Activin A, a multifunctional cytokine, is a member of TGF-β superfamily. Activin A first binds to the type II activin receptors (ActIIRA or ActRIIB) on the member surface, and then recruits and phosphorylates type I activin receptors (ActRI). Activin A primarily signal through SMAD2/3 proteins to regulate a variety of functions, including inflammation, fibrosis, and tumorigenesis. Activin A Protein, Human/Mouse/Rat (HEK293) is produced in HEK293 cells, and consists of 117 amino acids (G310-S426).
  • HY-P700159AF
    Animal-Free Activin A Protein, Human/Mouse/Rat (His)

    Activin beta-A chain; EDF; Erythroid differentiation factor; Erythroid differentiation protein; Follicle stimulating hormone releasing protein; FRP; FSH releasing protein; INHBA; INHBA_HUMAN; Inhibin beta A chain; Inhibin beta A subunit; Inhibin, beta 1; Inhibin, beta A activin A, activin AB alpha polypeptide;

    		Human; Rat; Mouse E. coli
    The INHBA protein plays a key role in regulating pituitary function by regulating follicle-stimulating hormone secretion together with activin. Its broad effects span a variety of physiological processes, including hormone secretion, germ cell development, erythrocyte differentiation, insulin secretion, nerve cell survival, embryonic development, and bone growth, depending on unique subunit composition. Animal-Free Activin A Protein, Human/Mouse/Rat (His) is the recombinant human, rat, mouse-derived animal-FreeActivin A protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free Activin A Protein, Human/Mouse/Rat (His) is 116 a.a., with molecular weight of ~13.9 kDa.
  • HY-P73241
    Activin A Protein, Mouse (HEK 293, His)

    Activin beta-A chain; Activin A; Inhibin beta A chain; INHBA

    		Mouse HEK293
    Activin A, a multifunctional cytokine, is a member of TGF-β superfamily. Activin A first binds to the type II activin receptors (ActIIRA or ActRIIB) on the member surface, and then recruits and phosphorylates type I activin receptors (ActRI). Activin A primarily signal through SMAD2/3 proteins to regulate a variety of functions, including inflammation, fibrosis, and tumorigenesis. Activin A Protein, Mouse (HEK293, His) is produced in HEK293 cellswith a C-Terminal His-tag. It  consists of 424 amino acids (M1-S424).
  • HY-P70311G
    GMP Activin A Protein, Human/Mouse/Rat (HEK293)

    rHuActivin A; Inhibin beta A chain; INHBA; Activin A

    		Rat; Mouse; Human HEK293
    The INHBA protein plays a key role in regulating pituitary function by regulating follicle-stimulating hormone secretion together with activin. Its broad effects span a variety of physiological processes, including hormone secretion, germ cell development, erythrocyte differentiation, insulin secretion, nerve cell survival, embryonic development, and bone growth, depending on unique subunit composition. GMP Activin A Protein, Human/Mouse/Rat (HEK293) is the recombinant rat, mouse, human-derived Activin A protein, expressed by HEK293 , with tag free. The total length of GMP Activin A Protein, Human/Mouse/Rat (HEK293) is 116 a.a., with molecular weight of 13-15 kDa.
  • HY-P73241A
    Activin A Protein, Mouse (HEK293, His)

    Activin beta-A chain; Activin A; Inhibin beta A chain; INHBA

    		Mouse HEK293
    Activin A, a multifunctional cytokine, is a member of TGF-β superfamily. Activin A first binds to the type II activin receptors (ActIIRA or ActRIIB) on the member surface, and then recruits and phosphorylates type I activin receptors (ActRI). Activin A primarily signal through SMAD2/3 proteins to regulate a variety of functions, including inflammation, fibrosis, and tumorigenesis. Activin A Protein, Mouse (HEK293, His) is produced in HEK293 cellswith a C-Terminal His-tag. It  consists of 404 amino acids (S21-S424).
Cat. No. Product Name Effect Purity