1. Recombinant Proteins
  2. Activin A Protein, Human/Mouse/Rat (HEK293)

Activin A Protein, Human/Mouse/Rat (HEK293)

Cat. No.: HY-P70311
Handling Instructions

Activin A Protein, Human/Mouse/Rat (HEK293) is a recombinant protein produced by HEK293 cells. Activin A, a multifunctional cytokine, is a member of transforming growth factor β (TGF β) superfamily. It is associated with a variety of pathophysiological processes, including inflammation, fibrosis, and tumorigenesis[1].

For research use only. We do not sell to patients.

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Size Price Stock Quantity
10 μg $170 In-stock
Estimated Time of Arrival: December 31
50 μg $510 In-stock
Estimated Time of Arrival: December 31
100 μg   Get quote  
250 μg   Get quote  

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  • Technical Parameters

  • Properties

  • Documentation

Synonyms
rHuActivin A; Inhibin beta A chain; INHBA; Activin A
Species

Human

Source

HEK 293

Accession

P08476 (G310-S426)

Gene ID

3624

Molecular Weight

Approximately 15.0 kDa

AA Sequence

GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Biological Activity
The ability to induce SMAD signaling in 293-Activin A Res cells has an ED50 value of 1.3 ng/mL.
Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US;may vary elsewhere.

Background

Activin A is expressed widely in various tissues and cells with strong bioactivities and is the mostly studied activin. It first binds to the type II activin receptors (ActIIRA or ActRIIB) on the member surface, and then recruits and phosphorylates type I activin receptors (ActRI). The phosphorylated ActRI activates Smad2 and Smad3, which form a complex with Smad4 to translocate to the nucleus. Activin and TGF-β share the same signaling pathway at the level of Smad2/3/4. Activin A exerts a variety of biological functions including regulation of hematopoietic cell proliferation, neuron differentiation, pituitary hormone secretion, and tissue repair. It is also involved in the process of many diseases, for example, inflammation, fibrosis and tumorigenesis[1].

Documentation
References
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Product Name:
Activin A Protein, Human/Mouse/Rat (HEK293)
Cat. No.:
HY-P70311
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