INHBA - inhibin subunit beta A Gene

Also Known as EDF; FRP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3624

About INHBA

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:41,685,114-41,705,406 (from NCBI)

This gene has 5 transcripts (splice variants), 281 orthologues, 31 paralogues and is associated with 1 phenotype. Broad expression in endometrium (RPKM 12.3), gall bladder (RPKM 11.3) and 15 other tissues.

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with Cancer cachexia in human patients. [provided by RefSeq, Aug 2016]

INHBA Products (1)

mRNA Protein Name
NM_002192.4 NP_002183.1 inhibin beta A chain preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
9884026 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
2575216 GOA
enables peptide hormone binding IPI
IPI: Inferred from physical interaction
16198295 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
2575216 GOA
enables type II activin receptor binding IPI
IPI: Inferred from physical interaction
7890768 GOA
Biological Process GO Annotation Evidence References Source
involved in GABAergic neuron differentiation IDA
IDA: Inferred from direct assay
25804741 GOA
involved in activin receptor signaling pathway IDA
IDA: Inferred from direct assay
9884026 GOA
involved in endodermal cell differentiation IDA
IDA: Inferred from direct assay
21828274 GOA
involved in extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
9884026 GOA
involved in hair follicle development IGI
IGI: Inferred from genetic interaction
10932194 GOA
involved in hematopoietic progenitor cell differentiation IDA
IDA: Inferred from direct assay
15451575 GOA
involved in hemoglobin biosynthetic process IDA
IDA: Inferred from direct assay
1310063 GOA
involved in male gonad development IGI
IGI: Inferred from genetic interaction
10932194 GOA
involved in negative regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
9884026 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
9884026 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11948405 GOA
involved in odontogenesis IGI
IGI: Inferred from genetic interaction
10932194 GOA
involved in ovarian follicle development IGI
IGI: Inferred from genetic interaction
10932194 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21281489 GOA
involved in positive regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
19736306 GOA
involved in positive regulation of erythrocyte differentiation IDA
IDA: Inferred from direct assay
9032295 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
8267637 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
23812417 GOA
involved in positive regulation of protein metabolic process IDA
IDA: Inferred from direct assay
21828274 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12702211 GOA
involved in progesterone secretion IGI
IGI: Inferred from genetic interaction
10932194 GOA
involved in regulation of follicle-stimulating hormone secretion IGI
IGI: Inferred from genetic interaction
10932194 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11948405 GOA
involved in roof of mouth development IGI
IGI: Inferred from genetic interaction
10932194 GOA
involved in striatal medium spiny neuron differentiation IDA
IDA: Inferred from direct assay
25804741 GOA
Cellular Component GO Annotation Evidence References Source
part of activin A complex IDA
IDA: Inferred from direct assay
7890768 GOA
part of enzyme activator complex IDA
IDA: Inferred from direct assay
12660162 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
12213882 GOA
part of inhibin A complex IDA
IDA: Inferred from direct assay
7890768 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INHBA Protein Structure

TGFb_propeptide

TGFb_propeptide: TGF-beta propeptide (48 - 295)

TGF_beta

TGF_beta: Transforming growth factor beta like domain (319 - 426)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
Protein Preferred Names Protein Names

inhibin beta A chain

  • FSH-releasing protein

INHBA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
INHBA P08476 Fst Rattus norvegicus P21674
ITC
16482217
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant INHBA Proteins

Cat. No. Product Name Accession Purity
HY-P70311 Activin A Protein, Human/Mouse/Rat (HEK293) P08476 (G311-S426) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700159AF Animal-Free Activin A Protein, Human/Mouse/Rat (His) P08476 (G311-S426) ≥ 95%, as determined by reducing SDS-PAGE.

INHBA Antibodies

Cat. No. Product Name Application Reactivity
HY-P83035 Inhibin beta A Antibody (YA2780) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Ovary Adenocarcinoma

  • Ovarian Adenocarcinoma

  • Adenocarcinoma Of The Ovary

  • Ovarian Adenoacanthoma

  • Adenocarcinoma Of Ovary
Sex Cord-Gonadal Stromal Tumor

  • Sex Cord-Gonadal Stromal Tumour

  • Sex Cord Stromal Tumour

  • Sex Cord-Stromal Neoplasm

  • Specialized Gonadal Neoplasm

  • Specialized Gonadal Tumor

  • Specialized Gonadal Tumour

  • Sex Cord-Gonadal Stromal Tumors

  • Sex Cord-Stromal Tumor

  • Malignant Testicular Sex Cord-Stromal Tumor

  • Sex Cord Stromal Tumor Of Testis
Clear Cell Adenocarcinoma

  • Mesonephroma

  • Water-Clear Cell Adenocarcinoma

  • Adenocarcinoma, Clear Cell

  • Malignant Mesonephroma

  • Mesonephroid Clear Cell Carcinoma

  • Mesonephroma, Malignant

  • Water-Clear Cell Carcinoma

  • Wolffian Duct Neoplasm

  • Adenocarcinoma Clear Cell

  • Mesonephric Tumor
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124447 BTYNB 98.0% Unkown
HY-RS06813 INHBA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17466 Inhba Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23924 Inhba Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus INHBA MGD MGI:96570
Macaca mulatta INHBA VGNC VGNC:81334
Canis familiaris INHBA VGNC VGNC:42021
Bos taurus INHBA VGNC VGNC:30200
Felis catus INHBA VGNC VGNC:80600
Rattus norvegicus INHBA RGD RGD:62074
Others INHBA NCBI