FST - Fst follistatin Gene

Also Known as FS; FOL1; Fst-288; RATFOL1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24373

Summary

Enables heparan sulfate proteoglycan binding activity. Predicted to be involved in hematopoietic progenitor cell differentiation; negative regulation of transcription by RNA polymerase II; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; keratinocyte proliferation; and positive regulation of hair follicle development. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (Follistatin). [provided by Alliance of Genome Resources, Apr 2022]

FST Products (1)

mRNA Protein Name
NM_012561.3 NP_036693.1 follistatin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables heparan sulfate proteoglycan binding IDA
IDA: Inferred from direct assay
12867435 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16482217 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
23567549 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
30599193 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

follistatin

  • activin-binding protein

  • follistatin-A

FST Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Fst P21674 INHBA Homo sapiens P08476
Chromatography
16482217
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1395 Mecamylamine hydrochloride 98.0% Yes
HY-B1395A Mecamylamine ≥90.0% Unkown

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101300 Cirazoline hydrochloride Agonist 99.56% Unkown
HY-W105505 SAMe-1,4-Butanedisulfonate 98.03% Unkown
HY-P1173 L803-mts Inhibitor 99.98% Unkown
HY-RS05127 FST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10321G PD173074 (GMP) Inhibitor / Unkown
HY-147735 GABAA receptor agonist 1 Agonist / Unkown
HY-147736 GABAA receptor agonist 2 Agonist / Unkown
HY-159942 5-HT7R antagonist 3 / Unkown
HY-169394 5-HT1AR agonist 2 / Unkown
HY-RS17065 Fst Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23509 Fst Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens FST NCBI NCBI:10468