FST - follistatin Gene

Also Known as FS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10468

About FST

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:53,480,629-53,487,134 (from NCBI)

This gene has 5 transcripts (splice variants), 245 orthologues and 6 paralogues. Broad expression in liver (RPKM 13.6), placenta (RPKM 7.9) and 16 other tissues.

Summary

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 Amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and Follistatin. [provided by RefSeq, Jul 2008]

FST Products (2)

mRNA	Protein	Name
NM_006350.5	NP_006341.1	follistatin isoform FST317 precursor
NM_013409.3	NP_037541.1	follistatin isoform FST344 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables activin binding	IPI IPI: Inferred from physical interaction	12697670	GOA
enables activin receptor antagonist activity	IMP IMP: Inferred from mutant phenotype	12702211	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16198295	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hematopoietic progenitor cell differentiation	IDA IDA: Inferred from direct assay	15451575	GOA
involved in negative regulation of activin receptor signaling pathway	IDA IDA: Inferred from direct assay	11948405	GOA
involved in negative regulation of activin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12702211	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12702211	GOA
acts upstream of or within positive regulation of hair follicle development	IDA IDA: Inferred from direct assay	12514121	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FST Protein Structure

FOLN

Kazal_2

0
100
200
300
344 a.a.

Protein Preferred Names	Protein Names
follistatin	activin-binding protein

FST Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FST	P19883	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	FST	P19883	DIP2A	Homo sapiens	Q14689	SPR	20860622
Intra	FST	P19883	ANG	Homo sapiens	P03950	Pull Down	17991437
Intra	FST	P19883	ANG	Homo sapiens	P03950	Confocal	17991437
Intra	FST	P19883	ANG	Homo sapiens	P03950	FRET	17991437
Intra	FST	P19883	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	FST	P19883	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	FST	P19883	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	FST	P19883	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	32296183
Intra	FST	P19883	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FST Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70315	Follistatin/FST Protein, Human (HEK293, His)	P19883-2 (G30-N317)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73068	Follistatin/FST Protein, Human (HEK293, Fc)	P19883-1/NP_037541.1 (G30-W344)	≥ 95%, as determined by reducing SDS-PAGE.

FST Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83102	Follistatin Antibody (YA2847)	WB	Human, Rat
HY-P83102A	Follistatin Antibody (YA2847)(PBS only)	WB	Human, Rat

Related Diseases

Diseases	Alias
Polycystic Ovary Syndrome	Polycystic Ovarian Syndrome Pcos Polycystic Ovarian Disease Polycystic Ovaries Stein-Leventhal Syndrome Multicystic Ovaries Polycystic Ovary Sclerocystic Ovaries Sclerocystic Ovary Syndrome Stein-Leventhal Synd. Cystic Disease Of Ovaries Cystic Disease Of Ovary Pco Pcod Sclerocystic Ovarian Degeneration Polycystic Ovary Syndrome, Susceptibility To Pcos - [Polycystic Ovary Syndrome] Polycystic Ovary Nos Pco - [Polycystic Ovary]
Orofacial Clefting Syndrome	Orofacial Clefting
Orofacial Cleft	Cleft, Orofacial
Teratocarcinoma	Mixed Embryonal Carcinoma And Teratoma
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Muscular Dystrophy, Becker Type	Becker Muscular Dystrophy BMD Benign Pseudohypertrophic Muscular Dystrophy Benign Congenital Myopathy Becker Dystrophinopathy Becker'S Muscular Dystrophy Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type Muscular Dystrophy Becker Dystrophy, Muscular, Becker Type Dystrophinopathy Becker Dystrophy Becker Type Dystrophy Bmd - [Becker Muscular Dystrophy]
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Myopathy	Muscular Diseases Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1395	Mecamylamine hydrochloride		98.0%	Yes
HY-B1395A	Mecamylamine		≥90.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101300	Cirazoline hydrochloride	Agonist	99.56%	Unkown
HY-W105505	SAMe-1,4-Butanedisulfonate		98.03%	Unkown
HY-P1173	L803-mts	Inhibitor	99.98%	Unkown
HY-RS05127	FST Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-10321G	PD173074 (GMP)	Inhibitor	/	Unkown
HY-147735	GABAA receptor agonist 1	Agonist	/	Unkown
HY-147736	GABAA receptor agonist 2	Agonist	/	Unkown
HY-159942	5-HT7R antagonist 3		/	Unkown
HY-169394	5-HT1AR agonist 2		/	Unkown
HY-RS17065	Fst Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23509	Fst Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FST	MGD	MGI:95586
Macaca mulatta	FST	VGNC	VGNC:72823
Canis familiaris	FST	VGNC	VGNC:51894
Rattus norvegicus	FST	RGD	RGD:2633
Bos taurus	FST	VGNC	VGNC:29134
Felis catus	FST	VGNC	VGNC:62379
Others	FST	NCBI