Follistatin Antibody (YA2847)(PBS only)

Cat. No.: HY-P83102A: Data Sheet User Guide for Antibodies
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Follistatin Antibody (YA2847) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Follistatin.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Follistatin Antibody (YA2847) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Follistatin.

Host

Rabbit

Molecular Weight

Predicted band size: 38 kDa;

Observed band size: 38 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Rat

SwissProt ID

P19883

Gene ID

10468 [NCBI]

Immunogen

Recombinant protein of human Follistatin

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs) (PubMed:11279126, PubMed:16482217, PubMed:18535106). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling (PubMed:16482217). Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin (By similarity). Also promotes neural differentiation by antagonizing the action BMP4 (By similarity). Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA (PubMed:11279126). On the other hand, translocates into the nucleus where it down-regulates rRNA synthesis and ribosome biogenesis to maintain cellular energy homeostasis by binding to rDNA

Subcellular Localization：Secreted; Nucleus, nucleolus

Expression：
Tissue_specificity:Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen throughout the palatal shelf and tongue mesenchyme (PubMed:31215115)

Induction:By glucose deprivation

Isoforms & Post-Translational Modification：P19883 has 2 isomers: P19883-1: 38007 Da (predicted); P19883-2: 34803 Da (predicted).

Subunit：Interacts with GDF11 (PubMed:18535106, PubMed:28257634). Interacts with activin A/INHBA (PubMed:11279126, PubMed:16482217, PubMed:18535106, PubMed:16198295, PubMed:17409095). Interacts with MYOSTATIN/MSTN (PubMed:18535106)

Research Field

Signal Transduction

Synonyms

Activin binding protein; Follistatin; FS; fst; Human follistatin gene

Documentation

User Guide for Antibodies (1077 KB)