1. Stem Cell/Wnt
  2. Wnt
    β-catenin
  3. MSAB

MSAB 

Cat. No.: HY-120697 Purity: 99.77%
Handling Instructions

MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells.

For research use only. We do not sell to patients.

MSAB Chemical Structure

MSAB Chemical Structure

CAS No. : 173436-66-3

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5 mg USD 85 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 300 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 680 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells[1].

IC50 & Target

Wnt/β-catenin[1]

In Vitro

MSAB (2-10 μM) selectively decreases cell viability of Wnt-dependent cells while showing little effect on Wnt-independent cells and normal human cells[1].
MSAB (0.01-10 μM; 20 h) inhibits T-cell factor (TCF) luciferase reporter activity in HCT116 cells[1].
MSAB (20 h) suppresses the Wnt3a-induced TOP-Luc activation and increases of active β-catenin levels in HEK293T cells[1].
MSAB (0.5-10 μM; 20 h) decreases mRNA and protein levels of endogenous Wnt target genes in HCT116 cells[1].
MSAB (5 μM; 16 h) induces degradation of β-catenin in a proteasome-dependent manner in HCT116 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MSAB (10-20 mg/kg; i.p. daily for 2 weeks) inhibits tumor growth of Wnt-dependent cancer cells in mouse xenograft model[1].
MSAB (10-20 mg/kg; i.p. twice daily for 2 weeks) inhibits tumor growth of MMTV-Wnt1 transgenic mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic nude mice (5-6 weeks) are injected HCT116, HT115, H23, or H460 cells[1]
Dosage: 10, 20 mg/kg
Administration: I.p. daily for 2 weeks
Result: Reduced the size and weight of various types of Wnt-dependent HCT116, HT115, and H23 tumors.
Molecular Weight

305.35

Formula

C₁₅H₁₅NO₄S

CAS No.

173436-66-3

SMILES

O=C(C1=CC=CC(NS(=O)(C2=CC=C(C=C2)C)=O)=C1)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (818.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2749 mL 16.3747 mL 32.7493 mL
5 mM 0.6550 mL 3.2749 mL 6.5499 mL
10 mM 0.3275 mL 1.6375 mL 3.2749 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MSABWntβ-cateninBeta catenindegradationanti-tumorcancerInhibitorinhibitorinhibit

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MSAB
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