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SNF8 - SNF8 subunit of ESCRT-II Gene

Also Known as Dot3; EAP30; VPS22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11267

About SNF8

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,929,316-48,944,842 (from NCBI)

This gene has 17 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in kidney (RPKM 18.5), fat (RPKM 18.4) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

SNF8 Products (4)

mRNA	Protein	Name
NM_001317192.2	NP_001304121.1	vacuolar-sorting protein SNF8 isoform 2
NM_001317193.2	NP_001304122.1	vacuolar-sorting protein SNF8 isoform 3
NM_001317194.2	NP_001304123.1	vacuolar-sorting protein SNF8 isoform 4
NM_007241.4	NP_009172.2	vacuolar-sorting protein SNF8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables channel regulator activity	IDA IDA: Inferred from direct assay	23171048	GOA
enables lipid binding	IPI IPI: Inferred from physical interaction	18539118	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14505570	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	14505570	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in early endosome to late endosome transport	IMP IMP: Inferred from mutant phenotype	17714434	GOA
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	17714434	GOA
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	38423010	GOA
involved in multivesicular body assembly	IMP IMP: Inferred from mutant phenotype	38423010	GOA
involved in multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	38423010	GOA
involved in positive regulation of exosomal secretion	IMP IMP: Inferred from mutant phenotype	22660413	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22978549	GOA
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	17959629	GOA
NOT involved in regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	17714434	GOA
involved in regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	17714434	GOA
involved in regulation of protein complex stability	IMP IMP: Inferred from mutant phenotype	17714434	GOA
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10419521	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESCRT II complex	IDA IDA: Inferred from direct assay	16973552	GOA
part of ESCRT II complex	IPI IPI: Inferred from physical interaction	18539118	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22978549	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17010938	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	16973552	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	17010938	GOA
located in membrane	IDA IDA: Inferred from direct assay	23171048	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23171048	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17714434	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22978549	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	17714434	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	10419521	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNF8 Protein Structure

EAP30

0
100
200
258 a.a.

Protein Preferred Names	Protein Names
vacuolar-sorting protein SNF8	EAP30 subunit of ELL complex

SNF8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNF8	Q96H20	AKAP9	Homo sapiens	Q6PJH3	Y2H Prey Pooling	32296183
Intra	SNF8	Q96H20	AKAP9	Homo sapiens	Q6PJH3	Y2H Array	32296183
Intra	SNF8	Q96H20	ELL	Homo sapiens	P55199	Anti Tag CoIP	19819239
Intra	SNF8	Q96H20	ELL	Homo sapiens	P55199	Competition Binding	19819239
Intra	SNF8	Q96H20	VAC14	Homo sapiens	Q08AM6	Y2H Array	29892012
Intra	SNF8	Q96H20	VAC14	Homo sapiens	Q08AM6	Validated Y2H	25416956
Intra	SNF8	Q96H20	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	SNF8	Q96H20	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	SNF8	Q96H20	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	SNF8	Q96H20	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	SNF8	Q96H20	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	SNF8	Q96H20	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	SNF8	Q96H20	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	SNF8	Q96H20	FANCL	Homo sapiens	Q9NW38	Validated Y2H	32296183
Intra	SNF8	Q96H20	STAU1	Homo sapiens	O95793-2	Anti Tag CoIP	22978549
Intra	SNF8	Q96H20	STAU1	Homo sapiens	O95793-2	Complementation	22978549
Intra	SNF8	Q96H20	MCM2	Homo sapiens	P49736	Y2H	19819239
Intra	SNF8	Q96H20	VPS36	Homo sapiens	Q86VN1	Anti Tag CoIP	35271311
Intra	SNF8	Q96H20	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	SNF8	Q96H20	CT55	Homo sapiens	Q8WUE5	Y2H Prey Pooling	32296183
Intra	SNF8	Q96H20	CT55	Homo sapiens	Q8WUE5	Y2H Array	32296183
Intra	SNF8	Q96H20	KDM1A	Homo sapiens	O60341	Y2H	23455924
Intra	SNF8	Q96H20	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	SNF8	Q96H20	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	SNF8	Q96H20	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	SNF8	Q96H20	VPS25	Homo sapiens	Q9BRG1	Anti Tag CoIP	35271311
Intra	SNF8	Q96H20	VPS25	Homo sapiens	Q9BRG1	Y2H Array	29892012
Intra	SNF8	Q96H20	VPS25	Homo sapiens	Q9BRG1	Y2H Pooling	16189514
Intra	SNF8	Q96H20	VPS25	Homo sapiens	Q9BRG1	Y2H Array	31515488
Intra	SNF8	Q96H20	VPS25	Homo sapiens	Q9BRG1	Y2H Prey Pooling	25416956
Intra	SNF8	Q96H20	VPS25	Homo sapiens	Q9BRG1	Y2H Prey Pooling	32296183
Intra	SNF8	Q96H20	VPS25	Homo sapiens	Q9BRG1	Validated Y2H	32296183
Intra	SNF8	Q96H20	VPS25	Homo sapiens	Q9BRG1	Y2H Array	25416956
Intra	SNF8	Q96H20	VPS25	Homo sapiens	Q9BRG1	Y2H Array	32296183
Intra	SNF8	Q96H20	PRMT6	Homo sapiens	Q96LA8	Y2H	23455924
Intra	SNF8	Q96H20	PRMT6	Homo sapiens	Q96LA8	Anti Tag CoIP	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

SNF8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89741	EAP30 Antibody (YA9085)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13490	SNF8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SNF8	RGD	RGD:1310144
Felis catus	SNF8	VGNC	VGNC:99457
Macaca mulatta	SNF8	VGNC	VGNC:77729
Mus musculus	SNF8	MGD	MGI:1343161
Canis familiaris	SNF8	VGNC	VGNC:46601
Bos taurus	SNF8	VGNC	VGNC:35064
Others	SNF8	NCBI