ELL - elongation factor for RNA polymerase II Gene

Homo sapiens

Also known as MEN; ELL1; PPP1R68; C19orf17

Gene ID: 8178 | Gene type: protein coding

About ELL

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,442,663-18,522,070 (from NCBI)

This gene has 6 transcripts (splice variants), 252 orthologues, 5 paralogues and is associated with 61 phenotypes. Broad expression in bone marrow (RPKM 9.4), testis (RPKM 9.4) and 25 other tissues.

Summary

Enables Phosphatase binding activity. Involved in positive regulation of transcription, DNA-templated and snRNA transcription. Located in cytosol; nuclear body; and transcriptionally active chromatin. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]

ELL Products(1)

mRNA	Protein	Name
NM_006532.4	NP_006523.1	RNA polymerase II elongation factor ELL

ELL Protein Structure

ELL

Occludin_ELL

0
100
200
300
400
500
621 a.a.

Protein Preferred Names

Protein Names

RNA polymerase II elongation factor ELL

ELL gene (11-19 lysine-rich leukemia gene)

Related Diseases

Diseases

Alias

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Acute Biphenotypic Leukemia

Mixed Phenotype Acute Leukemia	Acute Leukemia Of Ambiguous Lineage
Acute Undifferentiated Leukemia	Acute Leukemia Of Indeterminate Lineage
Hybrid Acute Leukemia	Mixed Lineage Acute Leukemia
All With Myeloid Markers	Aml With Lymphoid Markers
Acute Leukemia Of Undetermined Lineage	Bal
Biphenotypic Acute Leukemia	Undifferentiated Acute Leukemia
Mpal	Acute Myeloid Leukemia, Minimal Differentiation, Fab M0
Leukemia, Biphenotypic, Acute

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-136509	CIL62	≥97.0%	Unkown
HY-RS04308	ELL Human Pre-designed siRNA Set A	/	Unkown
HY-RS04309	ELL2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS04310	ELL3 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ELL	VGNC	VGNC:40306
Mus musculus	ELL	MGD	MGI:109377
Bos taurus	ELL	VGNC	VGNC:28435
Felis catus	ELL	VGNC	VGNC:61813
Macaca mulatta	ELL	VGNC	VGNC:72088
Rattus norvegicus	ELL	RGD	RGD:1311121
Macaca fascicularis	ELL	NCBI
Canis lupus familiaris	ELL	NCBI
Susscrofa domestica	ELL	NCBI
Others	ELL	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.