VPS36 - vacuolar protein sorting 36 homolog Gene

Also Known as EAP45; C13orf9; CGI-145

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51028

About VPS36

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:52,412,606-52,450,634 (from NCBI)

This gene has 9 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in skin (RPKM 25.0), thyroid (RPKM 15.1) and 25 other tissues.

Summary

This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]

VPS36 Products (3)

mRNA	Protein	Name
NM_001282168.2	NP_001269097.1	vacuolar protein-sorting-associated protein 36 isoform 2
NM_001282169.2	NP_001269098.1	vacuolar protein-sorting-associated protein 36 isoform 3
NM_016075.4	NP_057159.2	vacuolar protein-sorting-associated protein 36 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14505570	GOA
enables ubiquitin binding	IMP IMP: Inferred from mutant phenotype	16973552	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESCRT II complex	IDA IDA: Inferred from direct assay	16973552	GOA
part of ESCRT II complex	IPI IPI: Inferred from physical interaction	18539118	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17010938	GOA
located in endosome	IDA IDA: Inferred from direct assay	20682791	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	17010938	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS36 Protein Structure

Vps36_ESCRT-II

EAP30

0
100
200
300
386 a.a.

Protein Preferred Names	Protein Names
vacuolar protein-sorting-associated protein 36	ELL-associated protein of 45 kDa

VPS36 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VPS36	Q86VN1	VPS25	Homo sapiens	Q9BRG1	Anti Tag CoIP	35271311
Intra	VPS36	Q86VN1	VPS25	Homo sapiens	Q9BRG1	Anti Tag CoIP	28514442
Intra	VPS36	Q86VN1	VPS25	Homo sapiens	Q9BRG1	Validated Y2H	32296183
Intra	VPS36	Q86VN1	SNF8	Homo sapiens	Q96H20	Validated Y2H	32296183
Intra	VPS36	Q86VN1	SNF8	Homo sapiens	Q96H20	Anti Tag CoIP	28514442
Intra	VPS36	Q86VN1	SNF8	Homo sapiens	Q96H20	Y2H Array	32296183
Intra	VPS36	Q86VN1	SNF8	Homo sapiens	Q96H20	Anti Tag CoIP	35271311
Intra	VPS36	Q86VN1	SNF8	Homo sapiens	Q96H20	Y2H Prey Pooling	32296183
Intra	VPS36	Q86VN1	SNF8	Homo sapiens	Q96H20	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Conventional Lipoma	Classic Type Lipoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15687	VPS36 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	VPS36	VGNC	VGNC:48286
Felis catus	VPS36	VGNC	VGNC:66966
Mus musculus	VPS36	MGD	MGI:1917410
Bos taurus	VPS36	VGNC	VGNC:36819
Rattus norvegicus	VPS36	RGD	RGD:1309754
Macaca mulatta	VPS36	VGNC	VGNC:79241
Others	VPS36	NCBI