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BEND5 - BEN domain containing 5 Gene

Also Known as C1orf165

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79656

About BEND5

This gene has 6 transcripts (splice variants) and 190 orthologues. Ubiquitous expression in ovary (RPKM 1.6), brain (RPKM 1.3) and 23 other tissues.

Summary

Predicted to enable DNA binding activity. Involved in negative regulation of transcription, DNA-templated. Predicted to be located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

BEND5 Products (5)

mRNA	Protein	Name
NM_001302082.2	NP_001289011.1	BEN domain-containing protein 5 isoform 2
NM_001349793.2	NP_001336722.1	BEN domain-containing protein 5 isoform 2
NM_001349794.2	NP_001336723.1	BEN domain-containing protein 5 isoform 2
NM_001349795.2	NP_001336724.1	BEN domain-containing protein 5 isoform 3
NM_024603.4	NP_078879.2	BEN domain-containing protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24722188	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	23468431	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BEND5 Protein Structure

BEN

0
100
200
300
400
421 a.a.

Protein Preferred Names	Protein Names
BEN domain-containing protein 5

BEND5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BEND5	Q7L4P6	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	25416956
Intra	BEND5	Q7L4P6	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	25416956
Intra	BEND5	Q7L4P6	RTP5	Homo sapiens	Q14D33	Y2H Prey Pooling	25416956
Intra	BEND5	Q7L4P6	RTP5	Homo sapiens	Q14D33	Validated Y2H	25416956
Intra	BEND5	Q7L4P6	LCE1B	Homo sapiens	Q5T7P3	Y2H Prey Pooling	25416956
Intra	BEND5	Q7L4P6	LCE1B	Homo sapiens	Q5T7P3	Y2H Array	25416956
Intra	BEND5	Q7L4P6	PRKAB2	Homo sapiens	O43741	Validated Y2H	25416956
Intra	BEND5	Q7L4P6	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	BEND5	Q7L4P6	PTGR2	Homo sapiens	Q8N8N7	Validated Y2H	32296183
Intra	BEND5	Q7L4P6	USP20	Homo sapiens	Q9Y2K6	Y2H Prey Pooling	25416956
Intra	BEND5	Q7L4P6	USP20	Homo sapiens	Q9Y2K6	Y2H Array	25416956
Intra	BEND5	Q7L4P6	ZGPAT	Homo sapiens	Q8N5A5	Y2H Prey Pooling	25416956
Intra	BEND5	Q7L4P6	EIF3D	Homo sapiens	O15371	Y2H Prey Pooling	25416956
Intra	BEND5	Q7L4P6	EIF3D	Homo sapiens	O15371	Y2H Array	25416956
Intra	BEND5	Q7L4P6	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	BEND5	Q7L4P6	BUD31	Homo sapiens	P41223	Validated Y2H	25416956
Intra	BEND5	Q7L4P6	BUD31	Homo sapiens	P41223	Y2H Prey Pooling	25416956
Intra	BEND5	Q7L4P6	BUD31	Homo sapiens	P41223	Y2H Array	25416956
Intra	BEND5	Q7L4P6	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
Intra	BEND5	Q7L4P6	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	BEND5	Q7L4P6	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	25416956
Intra	BEND5	Q7L4P6	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	29892012
Intra	BEND5	Q7L4P6	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
Intra	BEND5	Q7L4P6	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	25416956
Intra	BEND5	Q7L4P6	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	BEND5	Q7L4P6	VPS25	Homo sapiens	Q9BRG1	Y2H Prey Pooling	25416956
Intra	BEND5	Q7L4P6	VPS25	Homo sapiens	Q9BRG1	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Leukoencephalopathy, Cystic, Without Megalencephaly	Cystic Leukoencephalopathy Without Megalencephaly Rnaset2-Deficient Cystic Leukoencephalopathy Rnase T2-Deficient Leukoencephalopathy Clwm Leukoencephalopathy With Bilateral Anterior Temporal Lobe Cysts Infantile-Onset Rnaset2 Deficient Cystic Leukoencephalopathy Lbatc LCWM

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01471	BEND5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22406	Bend5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28930	Bend5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BEND5	VGNC	VGNC:26468
Mus musculus	BEND5	MGD	MGI:1914871
Rattus norvegicus	BEND5	RGD	RGD:1584958
Others	BEND5	NCBI