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ZGPAT - zinc finger CCCH-type and G-patch domain containing Gene

Also Known as ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84619

About ZGPAT

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,707,442-63,736,142 (from NCBI)

This gene has 11 transcripts (splice variants), 199 orthologues and 2 paralogues. Ubiquitous expression in liver (RPKM 22.1), kidney (RPKM 17.5) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZGPAT Products (5)

mRNA	Protein	Name
NM_001083113.2	NP_001076582.1	zinc finger CCCH-type with G patch domain-containing protein isoform c
NM_001195653.2	NP_001182582.1	zinc finger CCCH-type with G patch domain-containing protein isoform c
NM_001195654.2	NP_001182583.1	zinc finger CCCH-type with G patch domain-containing protein isoform d
NM_032527.5	NP_115916.3	zinc finger CCCH-type with G patch domain-containing protein isoform a
NM_181485.3	NP_852150.2	zinc finger CCCH-type with G patch domain-containing protein isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19644445	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19644445	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19644445	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19644445	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19644445	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19644445	GOA
involved in negative regulation of epidermal growth factor-activated receptor activity	IDA IDA: Inferred from direct assay	19644445	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19644445	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	19644445	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZGPAT Protein Structure

G-patch

0
100
200
300
400
500
531 a.a.

Protein Preferred Names	Protein Names
zinc finger CCCH-type with G patch domain-containing protein	g patch domain-containing protein 6

ZGPAT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZGPAT	Q8N5A5	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	TP53BP2	Homo sapiens	Q13625-3	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	TP53BP2	Homo sapiens	Q13625-3	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	ZGPAT	Q8N5A5	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	DHX15	Homo sapiens	O43143	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	DHX15	Homo sapiens	O43143	Anti Tag CoIP	19644445
Intra	ZGPAT	Q8N5A5	DHX15	Homo sapiens	O43143	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	DHX15	Homo sapiens	O43143	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	KIFC3	Homo sapiens	Q9BVG8	Y2H	21516116
Intra	ZGPAT	Q8N5A5	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	SSX2IP	Homo sapiens	Q9Y2D8	Y2H	21516116
Intra	ZGPAT	Q8N5A5	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	CCDC57	Homo sapiens	Q2TAC2	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	PHC2	Homo sapiens	Q8IXK0	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	PHC2	Homo sapiens	Q8IXK0	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	BEND5	Homo sapiens	Q7L4P6	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	BEND5	Homo sapiens	Q7L4P6	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	KRT15	Homo sapiens	P19012	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	DYDC1	Homo sapiens	Q8WWB3	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	DYDC1	Homo sapiens	Q8WWB3	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	DYDC1	Homo sapiens	Q8WWB3	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
Intra	ZGPAT	Q8N5A5	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	AIMP2	Homo sapiens	Q13155	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	AIMP2	Homo sapiens	Q13155	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	AIMP2	Homo sapiens	Q13155	Validated Y2H	25416956
Intra	ZGPAT	Q8N5A5	STAC3	Homo sapiens	Q96MF2	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	25416956
Intra	ZGPAT	Q8N5A5	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	25416956
Intra	ZGPAT	Q8N5A5	CCNDBP1	Homo sapiens	O95273	Y2H	21516116

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Melnick-Needles Syndrome	MNS Melnick-Needles Osteodysplasty Osteodysplasty Of Melnick And Needles Osteochondrodysplasias
Otopalatodigital Syndrome Spectrum Disorder	Opd Spectrum Disorder Opsd Fronto-Otopalatodigital Osteodysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16066	ZGPAT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZGPAT	MGD	MGI:2449939
Macaca mulatta	ZGPAT	VGNC	VGNC:98469
Canis familiaris	ZGPAT	VGNC	VGNC:54747
Bos taurus	ZGPAT	VGNC	VGNC:57036
Rattus norvegicus	ZGPAT	RGD	RGD:1310801
Others	ZGPAT	NCBI