BLZF1 - basic leucine zipper nuclear factor 1 Gene

Also Known as JEM1; JEM-1; JEM-1s; GOLGIN-45

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8548

About BLZF1

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,368,195-169,396,575 (from NCBI)

This gene has 5 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in testis (RPKM 12.9), esophagus (RPKM 10.8) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Acts upstream of or within Golgi organization and Golgi to plasma membrane protein transport. Located in Golgi apparatus and nucleoplasm. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

BLZF1 Products (3)

mRNA	Protein	Name
NM_001320972.2	NP_001307901.1	golgin-45 isoform 2
NM_001320973.2	NP_001307902.1	golgin-45 isoform 1
NM_003666.4	NP_003657.1	golgin-45 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	21478859	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20211142	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	21478859	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Golgi organization	IDA IDA: Inferred from direct assay	11739401	GOA
acts upstream of or within Golgi to plasma membrane protein transport	IDA IDA: Inferred from direct assay	11739401	GOA

Cellular Component GO Annotation	Evidence	References	Source
NOT located in nucleus	IDA IDA: Inferred from direct assay	11739401	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9129147	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BLZF1 Protein Structure

DASH_Hsk3

0
100
200
300
400 a.a.

Protein Preferred Names	Protein Names
golgin-45	JEM-1short protein

BLZF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BLZF1	Q9H2G9	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	BLZF1	Q9H2G9	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	AMOTL2	Homo sapiens	Q9Y2J4-4	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	IQUB	Homo sapiens	Q8NA54	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	VPS28	Homo sapiens	Q548N1	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	FBF1	Homo sapiens	Q8TES7-6	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	FBF1	Homo sapiens	Q8TES7-6	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	TSC22D4	Homo sapiens	Q8IV54	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	OAZ3	Homo sapiens	Q9UMX2	Y2H Array	31515488
Intra	BLZF1	Q9H2G9	OAZ3	Homo sapiens	Q9UMX2	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	OAZ3	Homo sapiens	Q9UMX2	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	PRKAB2	Homo sapiens	O43741	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	PRKAB2	Homo sapiens	O43741	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	TRAPPC2L	Homo sapiens	Q9UL33-2	Validated Y2H	32296183
Intra	BLZF1	Q9H2G9	ZIM2	Homo sapiens	Q9NZV7	Validated Y2H	32296183
Intra	BLZF1	Q9H2G9	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	BLZF1	Q9H2G9	FAM124B	Homo sapiens	Q9H5Z6-2	Validated Y2H	32296183
Intra	BLZF1	Q9H2G9	PCDHB12	Homo sapiens	Q9Y5F1	Validated Y2H	32296183
Intra	BLZF1	Q9H2G9	SSX2	Homo sapiens	Q16385	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	SSX2	Homo sapiens	Q16385	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	SSX2	Homo sapiens	Q16385	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	BLZF1	Q9H2G9	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	BLZF1	Q9H2G9	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	BLZF1	Q9H2G9	TXNDC5	Homo sapiens	Q86UY0	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	TBC1D7	Homo sapiens	Q9P0N9	Validated Y2H	32296183
Intra	BLZF1	Q9H2G9	ZGPAT	Homo sapiens	Q8N5A5	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	ZGPAT	Homo sapiens	Q8N5A5	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	SMAD3	Homo sapiens	P84022	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	SMAD3	Homo sapiens	P84022	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	BLZF1	Q9H2G9	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	BLZF1	Q9H2G9	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	BLZF1	Q9H2G9	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	BLZF1	Q9H2G9	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	BLZF1	Q9H2G9	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	BLZF1	Q9H2G9	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	BLZF1	Q9H2G9	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	BLZF1	Q9H2G9	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	BLZF1	Q9H2G9	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	RAB2B	Homo sapiens	Q8WUD1	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	RAB2B	Homo sapiens	Q8WUD1	Y2H Array	32296183
Intra	BLZF1	Q9H2G9	RAB2B	Homo sapiens	Q8WUD1	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	RHOJ	Homo sapiens	Q9H4E5	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	KLHL38	Homo sapiens	Q2WGJ6	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	FHL2	Homo sapiens	Q14192	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	FHL2	Homo sapiens	Q14192	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	ZNF410	Homo sapiens	Q86VK4	Y2H Array	20211142
Intra	BLZF1	Q9H2G9	ZNF410	Homo sapiens	Q86VK4	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	ZNF410	Homo sapiens	Q86VK4	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	ZNF410	Homo sapiens	Q86VK4	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	GORASP2	Homo sapiens	Q9H8Y8	Anti Tag CoIP	33961781
Intra	BLZF1	Q9H2G9	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	CINP	Homo sapiens	Q9BW66	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	CINP	Homo sapiens	Q9BW66	Y2H Array	31515488
Intra	BLZF1	Q9H2G9	CINP	Homo sapiens	Q9BW66	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	HOXA1	Homo sapiens	P49639	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	TCF19	Homo sapiens	Q9Y242	Validated Y2H	32296183
Intra	BLZF1	Q9H2G9	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
Intra	BLZF1	Q9H2G9	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
Intra	BLZF1	Q9H2G9	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053
Intra	BLZF1	Q9H2G9	FRMD6	Homo sapiens	Q96NE9	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	FRMD6	Homo sapiens	Q96NE9	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	CHCHD3	Homo sapiens	Q9NX63	Validated Y2H	32296183
Intra	BLZF1	Q9H2G9	CHCHD3	Homo sapiens	Q9NX63	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	GEM	Homo sapiens	P55040	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	BEX2	Homo sapiens	Q9BXY8	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	BLZF1	Q9H2G9	TRAPPC2L	Homo sapiens	Q9UL33	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	SCNM1	Homo sapiens	Q9BWG6	Y2H Array	32296183
Intra	BLZF1	Q9H2G9	SCNM1	Homo sapiens	Q9BWG6	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	CARD9	Homo sapiens	Q9H257	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	RAB2A	Homo sapiens	P61019	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	RAB2A	Homo sapiens	P61019	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	RAB2A	Homo sapiens	P61019	Y2H Prey Pooling	25416956
Intra	BLZF1	Q9H2G9	BCL6	Homo sapiens	P41182	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	BCL6	Homo sapiens	P41182	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	KIF9	Homo sapiens	Q9HAQ2	Validated Y2H	32296183
Intra	BLZF1	Q9H2G9	LMO1	Homo sapiens	P25800	Validated Y2H	25416956
Intra	BLZF1	Q9H2G9	LMO1	Homo sapiens	P25800	Y2H Array	25416956
Intra	BLZF1	Q9H2G9	TBC1D22B	Homo sapiens	Q9NU19	Validated Y2H	32296183
Intra	BLZF1	Q9H2G9	AKAP9	Homo sapiens	Q99996-2	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Paraneoplastic Cerebellar Degeneration	Pcd Paraneoplastic Cerebellar Ataxia Rapidely Progressive Cerebellar Syndrome Subacute Cerebellar Degeneration
Lissencephaly, X-Linked, 1	Lissencephaly Type 1 Due To Doublecortin Gene Mutation Xlis Lissencephaly, X-Linked LISX1 Lissencephaly And Agenesis Of Corpus Callosum Subcortical Laminal Heterotopia, X-Linked X-Linked Lissencephaly 1 X-Linked Lissencephaly Double Cortex Xlis1 Lissencephaly X-Linked Lisx X-Linked Lissencephaly Type 1 Lissencephaly, X-Linked 1 Subcortical Band Heterotopia X-Linked SBHX Sclh Subcortical Laminar Heterotopia Lissencephaly, X-Linked, Type 1 Subcortical Band Heterotopia
Brucellosis	Mediterranean Fever Malta Fever Undulant Fever Gibraltar Fever Bang'S Disease Maltese Fever Cyprus Fever Rock Fever Brucellosis Infection Brucella Infection
Cryptococcosis	Cryptococcus Neoformans Infection Torulosis Busse-Buschke'S Disease Cryptococcal Infection European Cryptococcosis Torula Infection By Cryptococcus Neoformans Cryptococcosis Infection European Blastomycosis European Blastomycotic Infection European Blastomycoses Infection Torula Histolytica Infection
Alexander Disease	Alexander'S Disease ALXDRD Alexanders Leukodystrophy Axd Demyelinogenic Leukodystrophy Megalencephaly In Infancy Accompanied By Progressive Spasticity And Dementia Alx Dysmyelinogenic Leukodystrophy Fibrinoid Degeneration Of Astrocytes Leukodystrophy With Rosenthal Fibers Alexander Disease Type Ii Axd Type Ii Alexander Disease Type I Axd Type I Alexanders Disease Alexander'S Leukodystrophy
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01528	BLZF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BLZF1	MGD	MGI:1201607
Felis catus	BLZF1	VGNC	VGNC:60127
Macaca mulatta	BLZF1	VGNC	VGNC:70258
Bos taurus	BLZF1	VGNC	VGNC:26512
Rattus norvegicus	BLZF1	RGD	RGD:1562452
Canis familiaris	BLZF1	VGNC	VGNC:38473
Others	BLZF1	NCBI