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CINP - cyclin dependent kinase 2 interacting protein Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51550

About CINP

Cytogenetic location: 14q32.31 Genomic coordinates (GRCh38): 14:102,348,282-102,362,890 (from NCBI)

This gene has 9 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in testis (RPKM 6.8), brain (RPKM 6.4) and 25 other tissues.

Summary

The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

CINP Products (2)

mRNA	Protein	Name
NM_001320046.2	NP_001306975.1	cyclin-dependent kinase 2-interacting protein isoform 2
NM_032630.3	NP_116019.1	cyclin-dependent kinase 2-interacting protein isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables preribosome binding	IDA IDA: Inferred from direct assay	35354024	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ribosomal large subunit biogenesis	IDA IDA: Inferred from direct assay	35354024	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cyclin-dependent kinase 2-interacting protein	CDK2-interacting protein

CINP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CINP	Q9BW66	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	CINP	Q9BW66	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	CINP	Q9BW66	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	MMADHC	Homo sapiens	Q9H3L0	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	MMADHC	Homo sapiens	Q9H3L0	Validated Y2H	32296183
Intra	CINP	Q9BW66	MMADHC	Homo sapiens	Q9H3L0	Y2H Array	32296183
Intra	CINP	Q9BW66	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	CINP	Q9BW66	CFAP161	Homo sapiens	Q6P656	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	CFAP161	Homo sapiens	Q6P656	Y2H Array	32296183
Intra	CINP	Q9BW66	MINAR1	Homo sapiens	Q9UPX6	Validated Y2H	32296183
Intra	CINP	Q9BW66	MINAR1	Homo sapiens	Q9UPX6	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	MINAR1	Homo sapiens	Q9UPX6	Y2H Array	32296183
Intra	CINP	Q9BW66	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	CINP	Q9BW66	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	INADL	Homo sapiens	A5PKX9	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	INADL	Homo sapiens	A5PKX9	Y2H Array	32296183
Intra	CINP	Q9BW66	CCDC112	Homo sapiens	Q8NEF3-2	Y2H Array	32296183
Intra	CINP	Q9BW66	CCDC112	Homo sapiens	Q8NEF3-2	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	CINP	Q9BW66	NDUFB7	Homo sapiens	P17568	Y2H Array	32296183
Intra	CINP	Q9BW66	NDUFB7	Homo sapiens	P17568	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	PRRX1	Homo sapiens	P54821	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	PRRX1	Homo sapiens	P54821	Y2H Array	32296183
Intra	CINP	Q9BW66	ZNF19	Homo sapiens	P17023	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	ZNF19	Homo sapiens	P17023	Y2H Array	32296183
Intra	CINP	Q9BW66	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CINP	Q9BW66	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	TXNRD3NB	Homo sapiens	Q6F5E7	Y2H Array	32296183
Intra	CINP	Q9BW66	TXNRD3NB	Homo sapiens	Q6F5E7	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	CINP	Q9BW66	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	CINP	Q9BW66	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	25416956
Intra	CINP	Q9BW66	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	CINP	Q9BW66	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	MZT1	Homo sapiens	Q08AG7	Y2H Array	32296183
Intra	CINP	Q9BW66	MZT1	Homo sapiens	Q08AG7	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	SNRPD2	Homo sapiens	P62316	Y2H Array	32296183
Intra	CINP	Q9BW66	SNRPD2	Homo sapiens	P62316	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	CINP	Q9BW66	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	CINP	Q9BW66	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	CINP	Q9BW66	PSMA1	Homo sapiens	P25786	Y2H Array	32296183
Intra	CINP	Q9BW66	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	CINP	Q9BW66	MAGEA3	Homo sapiens	P43357	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	MAGEA3	Homo sapiens	P43357	Y2H Array	32296183
Intra	CINP	Q9BW66	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	CINP	Q9BW66	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	CINP	Q9BW66	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	CINP	Q9BW66	BTBD2	Homo sapiens	Q9BX70	Y2H Array	32296183
Intra	CINP	Q9BW66	BTBD2	Homo sapiens	Q9BX70	Validated Y2H	32296183
Intra	CINP	Q9BW66	BTBD2	Homo sapiens	Q9BX70	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	FAM161B	Homo sapiens	Q96MY7	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	FAM161B	Homo sapiens	Q96MY7	Y2H Array	32296183
Intra	CINP	Q9BW66	CLUAP1	Homo sapiens	Q96AJ1	Y2H Array	32296183
Intra	CINP	Q9BW66	CLUAP1	Homo sapiens	Q96AJ1	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	PRC1	Homo sapiens	O43663	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	PRC1	Homo sapiens	O43663	Y2H Array	32296183
Intra	CINP	Q9BW66	FNDC11	Homo sapiens	Q9BVV2	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	FNDC11	Homo sapiens	Q9BVV2	Y2H Array	32296183
Intra	CINP	Q9BW66	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	CINP	Q9BW66	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	CINP	Q9BW66	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	CINP	Q9BW66	ATRIP	Homo sapiens	Q8WXE1	Anti Bait CoIP	19889979
Intra	CINP	Q9BW66	ATRIP	Homo sapiens	Q8WXE1	Validated Y2H	25416956
Intra	CINP	Q9BW66	ATRIP	Homo sapiens	Q8WXE1	Y2H Array	25416956
Intra	CINP	Q9BW66	ATRIP	Homo sapiens	Q8WXE1	Anti Tag CoIP	19889979
Intra	CINP	Q9BW66	ATRIP	Homo sapiens	Q8WXE1	Y2H Prey Pooling	25416956
Intra	CINP	Q9BW66	ATRIP	Homo sapiens	Q8WXE1	Y2H	19889979
Intra	CINP	Q9BW66	SERTAD1	Homo sapiens	Q9UHV2	Validated Y2H	32296183
Intra	CINP	Q9BW66	SERTAD1	Homo sapiens	Q9UHV2	Y2H Array	32296183
Intra	CINP	Q9BW66	SERTAD1	Homo sapiens	Q9UHV2	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	AIRIM	Homo sapiens	Q9NX04	Y2H Array	32296183
Intra	CINP	Q9BW66	AIRIM	Homo sapiens	Q9NX04	Anti Tag CoIP	28514442
Intra	CINP	Q9BW66	AIRIM	Homo sapiens	Q9NX04	Anti Tag CoIP	33961781
Intra	CINP	Q9BW66	AIRIM	Homo sapiens	Q9NX04	Y2H Prey Pooling	25416956
Intra	CINP	Q9BW66	AIRIM	Homo sapiens	Q9NX04	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	CINP	Q9BW66	AIRIM	Homo sapiens	Q9NX04	Y2H Array	25416956
Intra	CINP	Q9BW66	SP2	Homo sapiens	Q02086-2	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	SP2	Homo sapiens	Q02086-2	Y2H Array	32296183
Intra	CINP	Q9BW66	COG3	Homo sapiens	Q96JB2-2	Y2H Prey Pooling	32296183
Intra	CINP	Q9BW66	COG3	Homo sapiens	Q96JB2-2	Y2H Array	32296183
Intra	CINP	Q9BW66	ATR	Homo sapiens	Q13535	Anti Bait CoIP	19889979
Intra	CINP	Q9BW66	ATR	Homo sapiens	Q13535	Anti Tag CoIP	19889979

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome	Jacobs Syndrome Arthropathy-Camptodactyly Syndrome Pericarditis-Arthropathy-Camptodactyly Syndrome Xyy Syndrome Pac Syndrome Cacp Syndrome CACP Fibrosing Serositis, Familial Camptodactyly-Arthropathy-Pericarditis Syndrome Cap Syndrome 47, Xyy Syndrome 47,Xyy Syndrome Double Y Syndrome Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome Hypertrophic Synovitis, Congenital Familial Congenital Familial Hypertrophic Synovitis Xyy Karyotype Y Disomy Yy Syndrome Familial Fibrosing Serositis Disomy Y Double Y Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome Arthropathy Camptodactyly Syndrome Camptodactyly Arthropathy Pericarditis Syndrome Pericarditis Arthropathy Camptodactyly Syndrome Jacob'S Syndrome 47,Xyy Cdags Syndrome
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13324	Bardoxolone methyl		99.66%	Yes

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02717	CINP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CINP	VGNC	VGNC:39276
Mus musculus	CINP	MGD	MGI:1914486
Macaca mulatta	CINP	VGNC	VGNC:71326
Rattus norvegicus	CINP	RGD	RGD:1563395
Felis catus	CINP	VGNC	VGNC:60905
Bos taurus	CINP	VGNC	VGNC:27368
Others	CINP	NCBI