SSX2IP - SSX family member 2 interacting protein Gene
Also Known as ADIP; hMsd1
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 117178
About SSX2IP
Cytogenetic location: 1p22.3
Genomic coordinates (GRCh38): 1:84,643,706-84,690,745 (from NCBI)
This gene has 10 transcripts (splice variants) and 276 orthologues. Broad expression in testis (RPKM 29.1), duodenum (RPKM 14.3) and 19 other tissues.
Summary
This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Oct 2009]
SSX2IP Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001166293.2 | NP_001159765.1 | afadin- and alpha-actinin-binding protein isoform 1 |
| NM_001166294.2 | NP_001159766.1 | afadin- and alpha-actinin-binding protein isoform 2 |
| NM_001166295.2 | NP_001159767.1 | afadin- and alpha-actinin-binding protein isoform 2 |
| NM_001166417.2 | NP_001159889.1 | afadin- and alpha-actinin-binding protein isoform 1 |
| NM_014021.4 | NP_054740.3 | afadin- and alpha-actinin-binding protein isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12007189 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in centrosome cycle |
IMP
IMP: Inferred from mutant phenotype
|
23816619 | GOA |
| involved in cilium assembly |
IMP
IMP: Inferred from mutant phenotype
|
24356449 | GOA |
| involved in intraciliary transport involved in cilium assembly |
IMP
IMP: Inferred from mutant phenotype
|
24356449 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in centriolar satellite |
IDA
IDA: Inferred from direct assay
|
23816619 | GOA |
| located in ciliary basal body |
IDA
IDA: Inferred from direct assay
|
24356449 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
afadin- and alpha-actinin-binding protein |
|
SSX2IP Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SSX2IP | Q9Y2D8 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | KRTAP10-7 | Homo sapiens | P60409 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | a8k932_human | Homo sapiens | A8K932 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TP53BP2 | Homo sapiens | Q13625-3 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | CCHCR1 | Homo sapiens | Q8TD31-3 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | CCHCR1 | Homo sapiens | Q8TD31-3 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TEAD4 | Homo sapiens | D3DUQ6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TEAD4 | Homo sapiens | D3DUQ6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ZNF250 | Homo sapiens | P15622-3 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ZNF250 | Homo sapiens | P15622-3 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | GOLGA8F | Homo sapiens | Q08AF8 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | GOLGA8F | Homo sapiens | Q08AF8 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | EIF4A2 | Homo sapiens | Q14240-2 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | CCDC198 | Homo sapiens | Q9NVL8 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | CCDC198 | Homo sapiens | Q9NVL8 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TBP | Homo sapiens | Q32MN6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TBP | Homo sapiens | Q32MN6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | FBF1 | Homo sapiens | Q8TES7-6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | FBF1 | Homo sapiens | Q8TES7-6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | LATS1 | Homo sapiens | Q6PJG3 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | LATS1 | Homo sapiens | Q6PJG3 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | SSX3 | Homo sapiens | Q99909 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | SSX3 | Homo sapiens | Q99909 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | SHFL | Homo sapiens | Q9NUL5 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | SHFL | Homo sapiens | Q9NUL5 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | POLL | Homo sapiens | Q9UGP5-2 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | MFAP1 | Homo sapiens | P55081 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | WRAP73 | Homo sapiens | Q9P2S5 | 33961781 | |
|
Intra
|
SSX2IP | Q9Y2D8 | WRAP73 | Homo sapiens | Q9P2S5 | 26638075 | |
|
Intra
|
SSX2IP | Q9Y2D8 | WRAP73 | Homo sapiens | Q9P2S5 | 26638075 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TFIP11 | Homo sapiens | Q9UBB9 | 31515488 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TFIP11 | Homo sapiens | Q9UBB9 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TFIP11 | Homo sapiens | Q9UBB9 | 25416956 | |
|
Cross
|
SSX2IP | Q9Y2D8 | Wrap73 | Mus musculus | Q9JM98 | 26675238 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ZSCAN12 | Homo sapiens | O43309 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | PRPF31 | Homo sapiens | Q8WWY3 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ZNF3 | Homo sapiens | P17036 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | MOS | Homo sapiens | P00540 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | MOS | Homo sapiens | P00540 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | MOS | Homo sapiens | P00540 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TRIM54 | Homo sapiens | Q9BYV2 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TRIM54 | Homo sapiens | Q9BYV2 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | SSX2 | Homo sapiens | Q16385 | 12007189 | |
|
Intra
|
SSX2IP | Q9Y2D8 | SSX2 | Homo sapiens | Q16385 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | SSX2 | Homo sapiens | Q16385 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | SSX2 | Homo sapiens | Q16385 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | EHHADH | Homo sapiens | Q08426 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | EHHADH | Homo sapiens | Q08426 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | FANCL | Homo sapiens | Q9NW38 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | MRPL53 | Homo sapiens | Q96EL3 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | PIMREG | Homo sapiens | Q9BSJ6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ZMAT2 | Homo sapiens | Q96NC0 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ZMAT2 | Homo sapiens | Q96NC0 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ZMAT2 | Homo sapiens | Q96NC0 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ATOSA | Homo sapiens | Q32MH5 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ATOSA | Homo sapiens | Q32MH5 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | YWHAH | Homo sapiens | Q04917 | 33961781 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ZGPAT | Homo sapiens | Q8N5A5 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ABLIM3 | Homo sapiens | O94929 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ABLIM3 | Homo sapiens | O94929 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | BYSL | Homo sapiens | Q13895 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | BYSL | Homo sapiens | Q13895 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | BYSL | Homo sapiens | Q13895 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | PSMA1 | Homo sapiens | P25786 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | PSMA1 | Homo sapiens | P25786 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | PSMA1 | Homo sapiens | P25786 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TOP3B | Homo sapiens | O95985 | 31515488 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TOP3B | Homo sapiens | O95985 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TOP3B | Homo sapiens | O95985 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | XIAP | Homo sapiens | P98170 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | XIAP | Homo sapiens | P98170 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | XIAP | Homo sapiens | P98170 | 31515488 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TRIM42 | Homo sapiens | Q8IWZ5 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TRIM42 | Homo sapiens | Q8IWZ5 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | CDCA7L | Homo sapiens | Q96GN5 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | CDCA7L | Homo sapiens | Q96GN5 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | WDR5 | Homo sapiens | P61964 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | PKN1 | Homo sapiens | Q16512 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | PKN1 | Homo sapiens | Q16512 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | PKN1 | Homo sapiens | Q16512 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ZNF587 | Homo sapiens | Q96SQ5 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ZNF587 | Homo sapiens | Q96SQ5 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TTC23 | Homo sapiens | Q5W5X9 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | ZRSR2 | Homo sapiens | Q15696 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | INO80B | Homo sapiens | Q9C086 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | NOL12 | Homo sapiens | Q9UGY1 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | NOL12 | Homo sapiens | Q9UGY1 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | FAM161A | Homo sapiens | Q3B820 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | FAM161A | Homo sapiens | Q3B820 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | EIF4A2 | Homo sapiens | Q14240 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | EIF4A2 | Homo sapiens | Q14240 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | KRT15 | Homo sapiens | P19012 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | LMO2 | Homo sapiens | P25791 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | KLHL42 | Homo sapiens | Q9P2K6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | KLHL42 | Homo sapiens | Q9P2K6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | KLHL42 | Homo sapiens | Q9P2K6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | C11orf54 | Homo sapiens | Q9H0W9 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | CCNH | Homo sapiens | P51946 | 21988832 | |
|
Intra
|
SSX2IP | Q9Y2D8 | CCNH | Homo sapiens | P51946 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | PCM1 | Homo sapiens | Q15154 | 24397932 | |
|
Intra
|
SSX2IP | Q9Y2D8 | PCM1 | Homo sapiens | Q15154 | 26638075 | |
|
Intra
|
SSX2IP | Q9Y2D8 | PCM1 | Homo sapiens | Q15154 | 24397932 | |
|
Intra
|
SSX2IP | Q9Y2D8 | PCM1 | Homo sapiens | Q15154 | 26638075 | |
|
Intra
|
SSX2IP | Q9Y2D8 | TRIM37 | Homo sapiens | O94972 | 26638075 | |
|
Intra
|
SSX2IP | Q9Y2D8 | FAM124B | Homo sapiens | Q9H5Z6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | FAM124B | Homo sapiens | Q9H5Z6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | FRMD6 | Homo sapiens | Q96NE9 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | CHCHD3 | Homo sapiens | Q9NX63 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | GEM | Homo sapiens | P55040 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | FNDC11 | Homo sapiens | Q9BVV2 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | FNDC11 | Homo sapiens | Q9BVV2 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | FNDC11 | Homo sapiens | Q9BVV2 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | BEX2 | Homo sapiens | Q9BXY8 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | BEX2 | Homo sapiens | Q9BXY8 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | BEX2 | Homo sapiens | Q9BXY8 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | NAA10 | Homo sapiens | P41227 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | CEP55 | Homo sapiens | Q53EZ4 | 26638075 | |
|
Intra
|
SSX2IP | Q9Y2D8 | CEP55 | Homo sapiens | Q53EZ4 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | SCNM1 | Homo sapiens | Q9BWG6 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | DAXX | Homo sapiens | Q9UER7 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | AEN | Homo sapiens | Q8WTP8 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | AEN | Homo sapiens | Q8WTP8 | 25416956 | |
|
Intra
|
SSX2IP | Q9Y2D8 | KRT31 | Homo sapiens | Q15323 | 25416956 | |
|
Cross
|
SSX2IP | Q9Y2D8 | tax | Human T-cell leukemia virus | P03410 | 22458338 | |
|
Cross
|
SSX2IP | Q9Y2D8 | tax | Human T-cell leukemia virus | P03410 | 22458338 | |
|
Cross
|
SSX2IP | Q9Y2D8 | tax | Human T-cell leukemia virus | P03410 | 22458338 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
SSX2IP Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82320 | SSX2IP Antibody (YA2065) | WB, IHC-F, IHC-P, ICC/IF | Human, Rat |
| HY-P82320A | SSX2IP Antibody (YA2065)(PBS only) | WB, IHC-F, IHC-P, ICC/IF | Human, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Distal Muscular Dystrophy With Anterior Tibial Onset |
|
|
| Sarcoma |
|
|
| Epiglottitis |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS13838 | SSX2IP Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | SSX2IP | VGNC | VGNC:77932 |
| Mus musculus | SSX2IP | MGD | MGI:2139150 |
| Canis familiaris | SSX2IP | VGNC | VGNC:46847 |
| Bos taurus | SSX2IP | VGNC | VGNC:35329 |
| Felis catus | SSX2IP | VGNC | VGNC:65716 |
| Rattus norvegicus | SSX2IP | RGD | RGD:708490 |
| Others | SSX2IP | NCBI |
Compound Screening Libraries
Virtual Screening
Customize Your Library
Drug Screening Service