PCM1 - pericentriolar material 1 Gene

Also Known as PTC4; RET/PCM-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5108

About PCM1

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,922,988-18,029,948 (from NCBI)

This gene has 22 transcripts (splice variants), 212 orthologues and is associated with 93 phenotypes. Broad expression in testis (RPKM 47.5), thyroid (RPKM 18.5) and 25 other tissues.

Summary

The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

PCM1 Products (32)

mRNA	Protein	Name
NM_001315507.2	NP_001302436.2	pericentriolar material 1 protein isoform 2
NM_001315508.2	NP_001302437.2	pericentriolar material 1 protein isoform 3
NM_001352632.2	NP_001339561.2	pericentriolar material 1 protein isoform 4
NM_001352633.2	NP_001339562.2	pericentriolar material 1 protein isoform 5
NM_001352634.2	NP_001339563.2	pericentriolar material 1 protein isoform 6
NM_001352635.2	NP_001339564.2	pericentriolar material 1 protein isoform 7
NM_001352636.2	NP_001339565.2	pericentriolar material 1 protein isoform 8
NM_001352637.2	NP_001339566.2	pericentriolar material 1 protein isoform 9
NM_001352638.2	NP_001339567.2	pericentriolar material 1 protein isoform 10
NM_001352639.2	NP_001339568.2	pericentriolar material 1 protein isoform 11
NM_001352640.2	NP_001339569.2	pericentriolar material 1 protein isoform 12
NM_001352641.2	NP_001339570.2	pericentriolar material 1 protein isoform 13
NM_001352642.2	NP_001339571.2	pericentriolar material 1 protein isoform 14
NM_001352643.2	NP_001339572.2	pericentriolar material 1 protein isoform 15
NM_001352644.2	NP_001339573.2	pericentriolar material 1 protein isoform 16
NM_001352645.2	NP_001339574.2	pericentriolar material 1 protein isoform 16
NM_001352646.2	NP_001339575.2	pericentriolar material 1 protein isoform 17
NM_001352647.2	NP_001339576.2	pericentriolar material 1 protein isoform 17
NM_001352648.2	NP_001339577.2	pericentriolar material 1 protein isoform 18
NM_001352649.2	NP_001339578.2	pericentriolar material 1 protein isoform 18
NM_001352650.2	NP_001339579.2	pericentriolar material 1 protein isoform 19
NM_001352651.2	NP_001339580.2	pericentriolar material 1 protein isoform 19
NM_001352652.2	NP_001339581.2	pericentriolar material 1 protein isoform 1
NM_001352653.2	NP_001339582.2	pericentriolar material 1 protein isoform 1
NM_001352654.2	NP_001339583.2	pericentriolar material 1 protein isoform 21
NM_001352655.2	NP_001339584.2	pericentriolar material 1 protein isoform 21
NM_001352656.2	NP_001339585.2	pericentriolar material 1 protein isoform 21
NM_001352657.2	NP_001339586.2	pericentriolar material 1 protein isoform 22
NM_001352658.2	NP_001339587.2	pericentriolar material 1 protein isoform 22
NM_001352659.2	NP_001339588.2	pericentriolar material 1 protein isoform 23
NM_001352660.2	NP_001339589.2	pericentriolar material 1 protein isoform 23
NM_006197.4	NP_006188.4	pericentriolar material 1 protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	34782749	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9361024	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	17574030	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	15616553	GOA
acts upstream of or within cytoplasmic microtubule organization	IMP IMP: Inferred from mutant phenotype	24816561	GOA
involved in cytoplasmic microtubule organization	IMP IMP: Inferred from mutant phenotype	22797915	GOA
involved in intraciliary transport involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	24550735	GOA
involved in non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	23789104	GOA
involved in positive regulation of intracellular protein transport	IMP IMP: Inferred from mutant phenotype	22797915	GOA
acts upstream of or within protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	24816561	GOA
involved in protein-containing complex localization to centriolar satellite	IDA IDA: Inferred from direct assay	34782749	GOA
involved in regulation of protein complex stability	IDA IDA: Inferred from direct assay	34782749	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in centriolar satellite	IDA IDA: Inferred from direct assay	34782749	GOA
located in centriolar satellite	IDA IDA: Inferred from direct assay	15616553	GOA
colocalizes with centrosome	IDA IDA: Inferred from direct assay	24648492	GOA
located in centrosome	IDA IDA: Inferred from direct assay	20719959	GOA
located in ciliary transition zone	IDA IDA: Inferred from direct assay	24415959	GOA
NOT located in non-motile cilium	IDA IDA: Inferred from direct assay	17574030	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	24421332	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
pericentriolar material 1 protein	PCM-1

PCM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PCM1	Q15154	BBS4	Homo sapiens	Q96RK4	Anti Tag CoIP	15107855
Intra	PCM1	Q15154	BBS4	Homo sapiens	Q96RK4	Y2H	15107855
Intra	PCM1	Q15154	BBS4	Homo sapiens	Q96RK4	Anti Tag CoIP	22500027
Intra	PCM1	Q15154	BBS4	Homo sapiens	Q96RK4	Confocal	15107855
Intra	PCM1	Q15154	MIB1	Homo sapiens	Q86YT6	Anti Tag CoIP	33961781
Intra	PCM1	Q15154	MIB1	Homo sapiens	Q86YT6	BioID	26638075
Intra	PCM1	Q15154	MIB1	Homo sapiens	Q86YT6	Anti Tag CoIP	26638075
Intra	PCM1	Q15154	SSX2IP	Homo sapiens	Q9Y2D8	BioID	26638075
Intra	PCM1	Q15154	SSX2IP	Homo sapiens	Q9Y2D8	Anti Tag CoIP	26638075
Intra	PCM1	Q15154	CEP131	Homo sapiens	Q9UPN4	Anti Tag CoIP	26638075
Intra	PCM1	Q15154	CEP131	Homo sapiens	Q9UPN4	Anti Bait CoIP	26297806
Intra	PCM1	Q15154	CEP131	Homo sapiens	Q9UPN4	BioID	26638075
Intra	PCM1	Q15154	PIBF1	Homo sapiens	Q8WXW3	BioID	26638075
Intra	PCM1	Q15154	PIBF1	Homo sapiens	Q8WXW3	Anti Tag CoIP	26638075
Intra	PCM1	Q15154	PIBF1	Homo sapiens	Q8WXW3	Anti Bait CoIP	26297806
Intra	PCM1	Q15154	KIAA0753	Homo sapiens	Q2KHM9	Anti Tag CoIP	26638075
Intra	PCM1	Q15154	KIAA0753	Homo sapiens	Q2KHM9	Anti Bait CoIP	26297806
Intra	PCM1	Q15154	KIAA0753	Homo sapiens	Q2KHM9	BioID	26638075
Intra	PCM1	Q15154	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	PCM1	Q15154	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	PCM1	Q15154	SPAG5	Homo sapiens	Q96R06	Anti Bait CoIP	26297806
Intra	PCM1	Q15154	PCNT	Homo sapiens	O95613	Anti Bait CoIP	24816561
Intra	PCM1	Q15154	PCNT	Homo sapiens	O95613	Anti Tag CoIP	26638075
Intra	PCM1	Q15154	GABARAP	Homo sapiens	O95166	Peptide Array	28712572
Intra	PCM1	Q15154	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	31515488
Intra	PCM1	Q15154	WASHC3	Homo sapiens	Q9Y3C0	Y2H Pooling	16189514
Intra	PCM1	Q15154	OFD1	Homo sapiens	O75665	BioID	26638075
Intra	PCM1	Q15154	OFD1	Homo sapiens	O75665	Anti Tag CoIP	26638075
Intra	PCM1	Q15154	CEP72	Homo sapiens	Q9P209	Y2H Array	31515488
Intra	PCM1	Q15154	CEP72	Homo sapiens	Q9P209	Anti Bait CoIP	26297806
Intra	PCM1	Q15154	CEP72	Homo sapiens	Q9P209	BioID	26638075
Intra	PCM1	Q15154	CEP72	Homo sapiens	Q9P209	Anti Tag CoIP	26638075
Intra	PCM1	Q15154	CEP72	Homo sapiens	Q9P209	Y2H Pooling	16189514
Intra	PCM1	Q15154	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	PCM1	Q15154	ABI2	Homo sapiens	Q9NYB9	Y2H Pooling	16189514
Intra	PCM1	Q15154	CCDC14	Homo sapiens	Q49A88	BioID	26638075
Intra	PCM1	Q15154	CCDC14	Homo sapiens	Q49A88	Anti Bait CoIP	26297806
Intra	PCM1	Q15154	CCDC14	Homo sapiens	Q49A88	Anti Tag CoIP	26638075
Cross	PCM1	Q15154	Hap1	Rattus norvegicus	P54256	Y2H	9361024
Cross	PCM1	Q15154	Hap1	Rattus norvegicus	P54256	Pull Down	9361024

Cross: Cross-species interaction Intra: Intraspecies interaction

PCM1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89969	PCM1 Antibody (YA9313)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Differentiated Thyroid Carcinoma	Papillary Or Follicular Thyroid Carcinoma Well-Differentiated Thyroid Carcinoma Differentiated Thyroid Gland Carcinoma
Bardet-Biedl Syndrome 4	BBS4 Bardet-Biedl Syndrome, Type 4
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Neurosyphilis	Syphilis Of Central Nervous System Late Syphilis Of Central Nervous System Nos Late Syphilis Of The Central Nervous System Gumma Of Central Nervous System Neurosyphilis Gumma Neurosyphilitic Gumma Syphilis Of Central Nervous System Nos Syphilitic Gumma Of Central Nervous System Tertiary Central Nervous System Syphilis
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08181	MBD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10156	PCM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22228	Mbd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PCM1	VGNC	VGNC:78544
Mus musculus	PCM1	MGD	MGI:1277958
Rattus norvegicus	PCM1	RGD	RGD:620901
Macaca mulatta	PCM1	VGNC	VGNC:75781
Canis familiaris	PCM1	VGNC	VGNC:44309
Bos taurus	PCM1	VGNC	VGNC:32634
Others	PCM1	NCBI