CEP72 - centrosomal protein 72 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55722

About CEP72

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:612,340-676,616 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 157 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in lung (RPKM 2.7), thyroid (RPKM 2.2) and 25 other tissues.

Summary

The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. [provided by RefSeq, Jul 2008]

CEP72 Products (1)

mRNA Protein Name
NM_018140.4 NP_060610.2 centrosomal protein of 72 kDa

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in centriole replication IMP
IMP: Inferred from mutant phenotype
26297806 GOA
involved in gamma-tubulin complex localization IMP
IMP: Inferred from mutant phenotype
19536135 GOA
involved in regulation of protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
26297806 GOA
involved in spindle organization IMP
IMP: Inferred from mutant phenotype
19536135 GOA
Cellular Component GO Annotation Evidence References Source
located in centriolar satellite IDA
IDA: Inferred from direct assay
26297806 GOA
located in centrosome IDA
IDA: Inferred from direct assay
19536135 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEP72 Protein Structure

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (54 - 92)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 647 a.a.
Protein Preferred Names Protein Names

centrosomal protein of 72 kDa

  • centrosomal protein 72kDa

CEP72 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CEP72 Q9P209 SFRS2 Homo sapiens Q6NXQ0
Validated Y2H
25416956
Intra
CEP72 Q9P209 CATIP Homo sapiens Q7Z7H3
Y2H Prey Pooling
25416956
Intra
CEP72 Q9P209 CATIP Homo sapiens Q7Z7H3
Y2H Array
25416956
Intra
CEP72 Q9P209 CATIP Homo sapiens Q7Z7H3
Validated Y2H
25416956
Intra
CEP72 Q9P209 KIZ Homo sapiens Q2M2Z5
Anti Bait CoIP
19536135
Intra
CEP72 Q9P209 PSMA1 Homo sapiens P25786
Y2H Array
25416956
Intra
CEP72 Q9P209 PSMA1 Homo sapiens P25786
Validated Y2H
25416956
Intra
CEP72 Q9P209 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
25416956
Intra
CEP72 Q9P209 SPATA24 Homo sapiens Q86W54
Anti Tag CoIP
33961781
Intra
CEP72 Q9P209 SPATA24 Homo sapiens Q86W54
Anti Tag CoIP
28514442
Intra
CEP72 Q9P209 SPATA24 Homo sapiens Q86W54
Y2H Array
25416956
Intra
CEP72 Q9P209 SPAG5 Homo sapiens Q96R06
Anti Bait CoIP
26297806
Intra
CEP72 Q9P209 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
CEP72 Q9P209 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
CEP72 Q9P209 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
CEP72 Q9P209 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
CEP72 Q9P209 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
25416956
Intra
CEP72 Q9P209 FAM90A1 Homo sapiens Q86YD7
Y2H Array
25416956
Intra
CEP72 Q9P209 ATXN7 Homo sapiens O15265
Y2H
21078624
Intra
CEP72 Q9P209 FXR1 Homo sapiens P51114
Anti Tag CoIP
21653829
Intra
CEP72 Q9P209 FXR1 Homo sapiens P51114
Y2H Pooling
21653829
Intra
CEP72 Q9P209 PIN4 Homo sapiens Q9Y237
Validated Y2H
25416956
Intra
CEP72 Q9P209 PIN4 Homo sapiens Q9Y237
Y2H Array
25416956
Intra
CEP72 Q9P209 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
Intra
CEP72 Q9P209 LNX1 Homo sapiens Q8TBB1
Y2H Pooling
16189514
Intra
CEP72 Q9P209 PCM1 Homo sapiens Q15154
Y2H Pooling
19447967
Intra
CEP72 Q9P209 NME7 Homo sapiens Q9Y5B8
Y2H Array
25416956
Intra
CEP72 Q9P209 NME7 Homo sapiens Q9Y5B8
Y2H Prey Pooling
25416956
Intra
CEP72 Q9P209 NME7 Homo sapiens Q9Y5B8
Validated Y2H
25416956
Intra
CEP72 Q9P209 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Intra
CEP72 Q9P209 STAMBPL1 Homo sapiens Q96FJ0
Y2H Prey Pooling
25416956
Intra
CEP72 Q9P209 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
CEP72 Q9P209 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
CEP72 Q9P209 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leukemia, Acute Lymphoblastic 3

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3

  • ALL3

  • Precursor B-Cell Acute Lymphoblastic Leukemia

  • B-All

  • Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma

  • Precursor B-Cell Acute Lymphocytic Leukemia

  • Precursor B-Cell Acute Lymphocytic Leukemia/Lymphoma

  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

  • Burkitt Lymphoma

  • Precursor B-Cell Lymphoblastic Leukemia
Precursor T-Cell Acute Lymphoblastic Leukemia

  • T-All

  • Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

  • Precursor T-Cell Acute Lymphocytic Leukemia

  • Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Adult T-Cell Lymphoma/Leukemia
Axonal Neuropathy
Autonomic Peripheral Neuropathy

  • Peripheral Autonomic Nervous System Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02522 CEP72 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CEP72 VGNC VGNC:39136
Rattus norvegicus CEP72 RGD RGD:1566336
Macaca mulatta CEP72 VGNC VGNC:71099
Felis catus CEP72 VGNC VGNC:60782
Mus musculus CEP72 MGD MGI:1921720
Bos taurus CEP72 VGNC VGNC:27212
Others CEP72 NCBI