CCDC14 - coiled-coil domain containing 14 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64770

About CCDC14

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:123,885,176-123,961,229 (from NCBI)

This gene has 22 transcripts (splice variants) and 159 orthologues. Ubiquitous expression in testis (RPKM 10.7), bone marrow (RPKM 8.7) and 25 other tissues.

Summary

Involved in protein localization to centrosome. Located in centriolar satellite. [provided by Alliance of Genome Resources, Apr 2022]

CCDC14 Products (7)

mRNA Protein Name
NM_001308317.2 NP_001295246.1 coiled-coil domain-containing protein 14 isoform 2
NM_001366335.1 NP_001353264.1 coiled-coil domain-containing protein 14 isoform 3
NM_001366336.1 NP_001353265.1 coiled-coil domain-containing protein 14 isoform 2
NM_001366337.1 NP_001353266.1 coiled-coil domain-containing protein 14 isoform 2
NM_001366338.1 NP_001353267.1 coiled-coil domain-containing protein 14 isoform 4
NM_001366339.1 NP_001353268.1 coiled-coil domain-containing protein 14 isoform 5
NM_022757.5 NP_073594.5 coiled-coil domain-containing protein 14 isoform 1
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17043677 GOA
Biological Process GO Annotation Evidence References Source
involved in protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
26297806 GOA
Cellular Component GO Annotation Evidence References Source
located in centriolar satellite IDA
IDA: Inferred from direct assay
26297806 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCDC14 Protein Structure

CCDC14

CCDC14: Coiled-coil domain-containing protein 14 (97 - 125)

CCDC14

CCDC14: Coiled-coil domain-containing protein 14 (126 - 912)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 912 a.a.
Protein Preferred Names Protein Names

coiled-coil domain-containing protein 14

CCDC14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCDC14 Q49A88 MAGEA11 Homo sapiens P43364-2 25416956
Intra
CCDC14 Q49A88 MAGEA11 Homo sapiens P43364-2 25416956
Intra
CCDC14 Q49A88 PEX5 Homo sapiens P50542 25416956
Intra
CCDC14 Q49A88 PEX5 Homo sapiens P50542 25416956
Intra
CCDC14 Q49A88 PCM1 Homo sapiens Q15154 26496610
Intra
CCDC14 Q49A88 CEP63 Homo sapiens Q96MT8 26297806
Intra
CCDC14 Q49A88 CEP63 Homo sapiens Q96MT8
Y2H
17043677
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noonan Syndrome 1
  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male

Theileriasis
  • Theileriosis

  • Infection By Theileria

Primary Autosomal Recessive Microcephaly
  • Autosomal Recessive Primary Microcephaly

  • Mcph

  • True Microcephaly

  • Microcephalia Vera

  • Microcephaly Vera

  • Microcephaly Primary Hereditary

  • Microcephaly, Primary, Autosomal Recessive

  • Primary Microcephaly

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus CCDC14 VGNC VGNC:26851
Felis catus CCDC14 VGNC VGNC:60462
Canis familiaris CCDC14 VGNC VGNC:38795
Mus musculus CCDC14 MGD MGI:2443448
Rattus norvegicus CCDC14 RGD RGD:1562189
Macaca mulatta CCDC14 VGNC VGNC:70863
Others CCDC14 NCBI