CCDC14 - coiled-coil domain containing 14 Gene
Species: Homo sapiens
About CCDC14
This gene has 22 transcripts (splice variants) and 159 orthologues. Ubiquitous expression in testis (RPKM 10.7), bone marrow (RPKM 8.7) and 25 other tissues.
Summary
Involved in protein localization to centrosome. Located in centriolar satellite. [provided by Alliance of Genome Resources, Apr 2022]
CCDC14 Products (7)
| mRNA | Protein | Name |
|---|---|---|
| NM_001308317.2 | NP_001295246.1 | coiled-coil domain-containing protein 14 isoform 2 |
| NM_001366335.1 | NP_001353264.1 | coiled-coil domain-containing protein 14 isoform 3 |
| NM_001366336.1 | NP_001353265.1 | coiled-coil domain-containing protein 14 isoform 2 |
| NM_001366337.1 | NP_001353266.1 | coiled-coil domain-containing protein 14 isoform 2 |
| NM_001366338.1 | NP_001353267.1 | coiled-coil domain-containing protein 14 isoform 4 |
| NM_001366339.1 | NP_001353268.1 | coiled-coil domain-containing protein 14 isoform 5 |
| NM_022757.5 | NP_073594.5 | coiled-coil domain-containing protein 14 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
17043677 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in protein localization to centrosome |
IMP
IMP: Inferred from mutant phenotype
|
26297806 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in centriolar satellite |
IDA
IDA: Inferred from direct assay
|
26297806 | GOA |
| located in centrosome |
IDA
IDA: Inferred from direct assay
|
21399614 | GOA |
CCDC14 Protein Structure
CCDC14: Coiled-coil domain-containing protein 14 (97 - 125)
CCDC14: Coiled-coil domain-containing protein 14 (126 - 912)
- 0
- 200
- 400
- 600
- 800
- 912 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
coiled-coil domain-containing protein 14 |
|
CCDC14 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CCDC14 | Q49A88 | MAGEA11 | Homo sapiens | P43364-2 | 25416956 | |
|
Intra
|
CCDC14 | Q49A88 | MAGEA11 | Homo sapiens | P43364-2 | 25416956 | |
|
Intra
|
CCDC14 | Q49A88 | PEX5 | Homo sapiens | P50542 | 25416956 | |
|
Intra
|
CCDC14 | Q49A88 | PEX5 | Homo sapiens | P50542 | 25416956 | |
|
Intra
|
CCDC14 | Q49A88 | PCM1 | Homo sapiens | Q15154 | 26496610 | |
|
Intra
|
CCDC14 | Q49A88 | CEP63 | Homo sapiens | Q96MT8 | 26297806 | |
|
Intra
|
CCDC14 | Q49A88 | CEP63 | Homo sapiens | Q96MT8 | 17043677 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Noonan Syndrome 1 |
|
|
| Theileriasis |
|
|
| Primary Autosomal Recessive Microcephaly |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | CCDC14 | VGNC | VGNC:26851 |
| Felis catus | CCDC14 | VGNC | VGNC:60462 |
| Canis familiaris | CCDC14 | VGNC | VGNC:38795 |
| Mus musculus | CCDC14 | MGD | MGI:2443448 |
| Rattus norvegicus | CCDC14 | RGD | RGD:1562189 |
| Macaca mulatta | CCDC14 | VGNC | VGNC:70863 |
| Others | CCDC14 | NCBI |