MIB1 - MIB E3 ubiquitin protein ligase 1 Gene

Also Known as MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57534

About MIB1

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:21,704,916-21,870,953 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 7.2), endometrium (RPKM 6.4) and 25 other tissues.

Summary

This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin Ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]

MIB1 Products (1)

mRNA Protein Name
NM_020774.4 NP_065825.1 E3 ubiquitin-protein ligase MIB1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21903422 GOA
Biological Process GO Annotation Evidence References Source
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
23615451 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIB1 Protein Structure

MIB_HERC2

MIB_HERC2: Mib_herc2 (15 - 74)

ZZ

ZZ: Zinc finger, ZZ type (80 - 119)

MIB_HERC2

MIB_HERC2: Mib_herc2 (154 - 220)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (435 - 527)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (531 - 593)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (596 - 662)

Ank

Ank: Ankyrin repeat (666 - 697)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (817 - 859)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (864 - 906)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (960 - 1001)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1006 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase MIB1

  • DAPK-interacting protein 1

MIB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
MIB1 Q86YT6 P0DTD1-PRO_0000449627 SARS-CoV-2 P0DTD1-PRO_0000449627
Y2H Array
36217030
Cross
MIB1 Q86YT6 Azi2 Mus musculus Q9QYP6
Anti Tag CoIP
21903422
Cross: Cross-species interaction Intra: Intraspecies interaction

MIB1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82146 MIB1 Antibody (YA1891) WB, IHC-P, ICC/IF Human, Mouse
HY-P84663 MIB1 Antibody (YA4360) WB, ICC/IF, FC, ELISA Human, Monkey
HY-P84663A MIB1 Antibody (YA4360)(PBS only) WB, ICC/IF, FC, ELISA Human, Monkey

Related Diseases

Diseases Alias
Left Ventricular Noncompaction 7

  • LVNC7

  • Left Ventricular Non-Compaction 7

  • Ventricular Noncompaction, Left, Type 7
Left Ventricular Noncompaction

  • Noncompaction Cardiomyopathy

  • Left Ventricular Hypertrabeculation

  • Lvnc

  • Spongy Myocardium

  • Isolated Noncompaction Of The Ventricular Myocardium

  • Left Ventricular Myocardial Noncompaction Cardiomyopathy

  • Fetal Myocardium

  • Honeycomb Myocardium

  • Hypertrabeculation Syndrome

  • Left Ventricular Non-Compaction

  • Lvht

  • Non-Compaction Of The Left Ventricular Myocardium

  • Ventricular Noncompaction, Left

  • Non-Compaction Cardiomyopathy
Lymphoplasmacyte-Rich Meningioma

  • Lymphoplasmocyte-Rich Meningioma

  • Meningioma
Microcystic Meningioma
Juxtacortical Chondroma

  • Periosteal Chondroma
Diffuse Meningeal Melanocytosis

  • Diffuse Melanocytosis

  • Diffuse Melanosis
Foster-Kennedy Syndrome

  • Disorder Of The Optic Nerve

  • Optic Nerve Diseases

  • Disease Of Optic Cranial Nerve

  • Disease Of Optic Nerve

  • Disease Of Second Cranial Nerve

  • Disorder Of Optic Cranial Nerve

  • Disorder Of Second Cranial Nerve

  • Disorders Of 2nd Nerve
Meningeal Melanocytoma

  • Leptomeningeal Melanocytoma

  • Melanocytoma Of Meninges
Central Nervous System Melanocytic Neoplasm

  • Primary Melanocytic Lesion Of Meninges

  • Central Nervous System Primary Melanocytic Lesion

  • Melanocytic Tumor Of The Cns

  • Primary Melanocytic Lesions Of The Cns
Spinal Meningioma

  • Spinal Cord Meningioma

  • Meningioma, Spine

  • Meningioma

  • Meningioma, Benign, No Icd-O Subtype
Spinal Canal And Spinal Cord Meningioma
Intracranial Meningioma

  • Meningioma
Optic Nerve Glioma

  • Glioma Of The Optic Nerve
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Optic Nerve Neoplasm

  • Optic Nerve Neoplasms

  • Neoplasm Of Optic Nerve

  • Tumor Of Second Cranial Nerve

  • Tumour Of Optic Nerve
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08422 MIB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08470 MKI67 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22234 Mib1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28756 Mib1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MIB1 MGD MGI:2443157
Rattus norvegicus MIB1 RGD RGD:1307195
Bos taurus MIB1 VGNC VGNC:31455
Macaca mulatta MIB1 VGNC VGNC:104228
Canis familiaris MIB1 VGNC VGNC:43217
Felis catus MIB1 VGNC VGNC:63492
Others MIB1 NCBI