Azi2 - 5-azacytidine induced gene 2 Gene

Also Known as AZ2; Nap1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 27215

Summary

Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; dendritic cell differentiation; and dendritic cell proliferation. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human AZI2 (5-azacytidine induced 2). [provided by Alliance of Genome Resources, Apr 2022]

Azi2 Products (4)

mRNA	Protein	Name
NM_001048146.2	NP_001041611.1	5-azacytidine-induced protein 2 isoform b
NM_001286507.1	NP_001273436.1	5-azacytidine-induced protein 2 isoform c
NM_001286508.1	NP_001273437.1	5-azacytidine-induced protein 2 isoform a
NM_013727.4	NP_038755.1	5-azacytidine-induced protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T cell activation	IDA IDA: Inferred from direct assay	23610142	MGI
acts upstream of or within T cell activation	IMP IMP: Inferred from mutant phenotype	23610142	MGI
acts upstream of or within cytokine production	IMP IMP: Inferred from mutant phenotype	23610142	MGI
acts upstream of or within dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	23610142	MGI
acts upstream of or within dendritic cell proliferation	IGI IGI: Inferred from genetic interaction	23610142	MGI
acts upstream of or within interleukin-6 production	IMP IMP: Inferred from mutant phenotype	23610142	MGI
acts upstream of or within mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	23610142	MGI
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	10580148	MGI
acts upstream of or within tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	23610142	MGI
acts upstream of or within type II interferon production	IMP IMP: Inferred from mutant phenotype	23610142	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10580148	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
5-azacytidine-induced protein 2	NF-kappa-B-activating kinase-associated protein 1 nak-associated protein 1

Azi2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Azi2	Q9QYP6	MIB1	Homo sapiens	Q86YT6	Anti Tag CoIP	21903422
Cross	Azi2	Q9QYP6	MTPAP	Homo sapiens	Q9NVV4	Anti Tag CoIP	21903422
Cross	Azi2	Q9QYP6	TRAF3	Homo sapiens	Q13114	Anti Tag CoIP	21903422
Cross	Azi2	Q9QYP6	TXLNA	Homo sapiens	P40222	Anti Tag CoIP	21903422
Cross	Azi2	Q9QYP6	N4BP1	Homo sapiens	O75113	Anti Tag CoIP	21903422
Cross	Azi2	Q9QYP6	APBA3	Homo sapiens	O96018	Anti Tag CoIP	21903422
Cross	Azi2	Q9QYP6	RNF31	Homo sapiens	Q96EP0	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS01295	AZI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01297	AZIN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Azi2	NCBI	NCBI:64343