N4BP1 - NEDD4 binding protein 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9683

About N4BP1

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:48,538,726-48,610,180 (from NCBI)

This gene has 6 transcripts (splice variants), 211 orthologues and 6 paralogues. Ubiquitous expression in lung (RPKM 13.3), esophagus (RPKM 11.1) and 25 other tissues.

Summary

Enables mRNA binding activity; ribonuclease activity; and ubiquitin binding activity. Involved in cellular response to UV and negative regulation of viral genome replication. Predicted to be located in cytosol and nucleolus. Predicted to be active in PML body. [provided by Alliance of Genome Resources, Apr 2022]

N4BP1 Products (1)

mRNA Protein Name
NM_153029.4 NP_694574.3 NEDD4-binding protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA nuclease activity IDA
IDA: Inferred from direct assay
31133753 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
31133753 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17592138 GOA
enables ubiquitin binding IDA
IDA: Inferred from direct assay
31319543 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to UV IMP
IMP: Inferred from mutant phenotype
17592138 GOA
involved in negative regulation of viral genome replication IDA
IDA: Inferred from direct assay
31133753 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

N4BP1 Protein Structure

RNase_Zc3h12a

RNase_Zc3h12a: Zc3h12a-like Ribonuclease NYN domain (617 - 768)

  • 0
  • 200
  • 400
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  • 800
  • 896 a.a.
Protein Preferred Names Protein Names

NEDD4-binding protein 1

N4BP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
N4BP1 O75113 ITCH Homo sapiens Q96J02
Pull Down
17592138
Intra
N4BP1 O75113 LITAF Homo sapiens Q99732
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08979 N4BP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus N4BP1 VGNC VGNC:31852
Felis catus N4BP1 VGNC VGNC:63701
Macaca mulatta N4BP1 VGNC VGNC:75051
Rattus norvegicus N4BP1 RGD RGD:1305179
Mus musculus N4BP1 MGD MGI:2136825
Canis familiaris N4BP1 VGNC VGNC:43596
Others N4BP1 NCBI