AZI2 - 5-azacytidine induced 2 Gene

Also Known as AZ2; NAP1; TILP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64343

About AZI2

Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38): 3:28,321,047-28,348,824 (from NCBI)

This gene has 14 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 22.5), thyroid (RPKM 15.3) and 25 other tissues.

Summary

AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]

AZI2 Products (4)

mRNA Protein Name
NM_001134432.2 NP_001127904.1 5-azacytidine-induced protein 2 isoform b
NM_001134433.2 NP_001127905.1 5-azacytidine-induced protein 2 isoform c
NM_001271650.2 NP_001258579.1 5-azacytidine-induced protein 2 isoform d
NM_022461.5 NP_071906.1 5-azacytidine-induced protein 2 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14743216 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AZI2 Protein Structure

TBD

TBD: TBD domain (212 - 265)

  • 0
  • 100
  • 200
  • 300
  • 392 a.a.
Protein Preferred Names Protein Names

5-azacytidine-induced protein 2

  • 5-azacytidine induced gene 2

AZI2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AZI2 Q9H6S1 TBK1 Homo sapiens Q9UHD2
TAP
14743216
Intra
AZI2 Q9H6S1 TBK1 Homo sapiens Q9UHD2
Lumier
21931555
Cross
AZI2 Q9H6S1 OPG029 vaccinia virus P17362
Affinity Techniques
21931555
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Vaccinia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01295 AZI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01297 AZIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus AZI2 MGD MGI:1351332
Rattus norvegicus AZI2 RGD RGD:1310530
Macaca mulatta AZI2 VGNC VGNC:70115
Felis catus AZI2 VGNC VGNC:102605
Canis familiaris AZI2 VGNC VGNC:38328
Bos taurus AZI2 VGNC VGNC:26368
Others AZI2 NCBI