AEN - apoptosis enhancing nuclease Gene

Homo sapiens

Also known as ISG20L1; pp12744

Gene ID: 64782 | Gene type: protein coding

About AEN

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:88,604,683-88,632,281 (from NCBI)

This gene has 6 transcripts (splice variants), 247 orthologues and 5 paralogues. Ubiquitous expression in gall bladder (RPKM 5.8), thyroid (RPKM 5.8) and 25 other tissues.

Summary

Enables exonuclease activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Located in nuclear membrane; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

AEN Products(1)

mRNA	Protein	Name
NM_022767.4	NP_073604.3	apoptosis-enhancing nuclease

AEN Protein Structure

RNase_T

0
100
200
300
325 a.a.

Protein Preferred Names

Protein Names

apoptosis-enhancing nuclease

interferon stimulated exonuclease gene 20kDa-like 1

Related Diseases

Diseases

Alias

Chest Wall Lymphoma

Chest Wall Cancer	Lymphoma Of Chest Wall
Lymphoma Of The Chest Wall	Malignant Neoplasm Of Chest Wall
Malignant Tumor Of Chest Wall

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00424	AEN Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AEN	RGD	RGD:1305051
Mus musculus	AEN	MGD	MGI:1915298
Canis familiaris	AEN	VGNC	VGNC:53144
Macaca mulatta	AEN	VGNC	VGNC:84297
Felis catus	AEN	VGNC	VGNC:59664
Bos taurus	AEN	VGNC	VGNC:25705
Others	AEN	NCBI