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AEN - apoptosis enhancing nuclease Gene

Also Known as ISG20L1; pp12744

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64782

About AEN

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:88,604,683-88,632,281 (from NCBI)

This gene has 6 transcripts (splice variants), 247 orthologues and 5 paralogues. Ubiquitous expression in gall bladder (RPKM 5.8), thyroid (RPKM 5.8) and 25 other tissues.

Summary

Enables exonuclease activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Located in nuclear membrane; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

AEN Products (1)

mRNA	Protein	Name
NM_022767.4	NP_073604.3	apoptosis-enhancing nuclease

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables DNA exonuclease activity	IDA IDA: Inferred from direct assay	18264133	GOA
enables exonuclease activity	IDA IDA: Inferred from direct assay	16171785	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA IDA: Inferred from direct assay	18264133	GOA
involved in response to ionizing radiation	IDA IDA: Inferred from direct assay	16171785	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in nucleolus	IDA IDA: Inferred from direct assay	18264133	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16171785	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AEN Protein Structure

RNase_T

0
100
200
300
325 a.a.

Protein Preferred Names	Protein Names
apoptosis-enhancing nuclease	interferon stimulated exonuclease gene 20kDa-like 1

AEN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	AEN	Q8WTP8	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	AEN	Q8WTP8	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	AEN	Q8WTP8	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	AEN	Q8WTP8	KRTAP10-5	Homo sapiens	P60370	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	25416956
Intra	AEN	Q8WTP8	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	AEN	Q8WTP8	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	AAMP	Homo sapiens	C9JG97	Validated Y2H	25416956
Intra	AEN	Q8WTP8	AAMP	Homo sapiens	C9JG97	Y2H Array	25416956
Intra	AEN	Q8WTP8	MBNL1	Homo sapiens	Q86VM6	Validated Y2H	25416956
Intra	AEN	Q8WTP8	RPGRIP1	Homo sapiens	Q96KN7	Validated Y2H	25416956
Intra	AEN	Q8WTP8	GNPTAB	Homo sapiens	Q3T906	Validated Y2H	25416956
Intra	AEN	Q8WTP8	PDE4DIP	Homo sapiens	Q5VU43	Y2H Array	25416956
Intra	AEN	Q8WTP8	ZNF317	Homo sapiens	Q96PQ6	Y2H Array	31515488
Intra	AEN	Q8WTP8	ZNF317	Homo sapiens	Q96PQ6	Validated Y2H	25416956
Intra	AEN	Q8WTP8	ZNF317	Homo sapiens	Q96PQ6	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	AEN	Q8WTP8	EXOSC8	Homo sapiens	Q96B26	Validated Y2H	25416956
Intra	AEN	Q8WTP8	EMD	Homo sapiens	P50402	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	ZFP64	Homo sapiens	Q9NTW7	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	ZFP64	Homo sapiens	Q9NTW7	Y2H Array	25416956
Intra	AEN	Q8WTP8	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	AEN	Q8WTP8	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	AEN	Q8WTP8	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	AEN	Q8WTP8	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	25416956
Intra	AEN	Q8WTP8	AAMP	Homo sapiens	Q13685	Anti Tag CoIP	33961781
Intra	AEN	Q8WTP8	AAMP	Homo sapiens	Q13685	Y2H Array	29892012
Intra	AEN	Q8WTP8	ZBTB43	Homo sapiens	O43298	Validated Y2H	25416956
Intra	AEN	Q8WTP8	ZBTB43	Homo sapiens	O43298	Y2H Array	25416956
Intra	AEN	Q8WTP8	ZBTB43	Homo sapiens	O43298	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	AEN	Q8WTP8	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	AEN	Q8WTP8	RALYL	Homo sapiens	Q86SE5	Y2H Array	25416956
Intra	AEN	Q8WTP8	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	25416956
Intra	AEN	Q8WTP8	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	AEN	Q8WTP8	IKZF1	Homo sapiens	Q13422	Y2H Array	25416956
Intra	AEN	Q8WTP8	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	ZNF473	Homo sapiens	Q8WTR7	Validated Y2H	25416956
Intra	AEN	Q8WTP8	ZNF473	Homo sapiens	Q8WTR7	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	ZNF473	Homo sapiens	Q8WTR7	Y2H Array	31515488
Intra	AEN	Q8WTP8	RBMY1A1	Homo sapiens	P0DJD3	Y2H Prey Pooling	25416956
Intra	AEN	Q8WTP8	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chest Wall Lymphoma	Chest Wall Cancer Lymphoma Of Chest Wall Lymphoma Of The Chest Wall Malignant Neoplasm Of Chest Wall Malignant Tumor Of Chest Wall

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS00424	AEN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19856	Aen Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26356	Aen Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AEN	RGD	RGD:1305051
Mus musculus	AEN	MGD	MGI:1915298
Canis familiaris	AEN	VGNC	VGNC:53144
Macaca mulatta	AEN	VGNC	VGNC:84297
Felis catus	AEN	VGNC	VGNC:59664
Bos taurus	AEN	VGNC	VGNC:25705
Others	AEN	NCBI