ZBTB8A - zinc finger and BTB domain containing 8A Gene

Also Known as BOZF1; ZBTB8; ZNF916A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 653121

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in endometrium (RPKM 3.1), thyroid (RPKM 2.7) and 25 other tissues.

ZBTB8A Products (2)

mRNA Protein Name
NM_001040441.3 NP_001035531.2 zinc finger and BTB domain-containing protein 8A isoform 1
NM_001291496.2 NP_001278425.1 zinc finger and BTB domain-containing protein 8A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
23329847 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
23329847 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
23329847 GOA
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
23329847 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23329847 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB8A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZBTB8A Q96BR9 a8k932_human Homo sapiens A8K932
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 a8k932_human Homo sapiens A8K932
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 UBE2I Homo sapiens Q7KZS0
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 ZNF138 Homo sapiens P52744-2
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 ZNF138 Homo sapiens P52744-2
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 ZNF509 Homo sapiens Q32MK9
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 ZNF509 Homo sapiens Q32MK9
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 SYT6 Homo sapiens Q5T7P8-2
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 ZNF276 Homo sapiens Q8N554-2
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 q9nwj2_human Homo sapiens Q9NWJ2
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 BAZ2B Homo sapiens Q9UIF8-2
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 HEL-S-61 Homo sapiens V9HW29
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 HEL-S-61 Homo sapiens V9HW29
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 MFAP1 Homo sapiens P55081
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 MFAP1 Homo sapiens P55081
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 PRR34 Homo sapiens Q9NV39
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 ZNF837 Homo sapiens Q96EG3
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 TNIP3 Homo sapiens Q96KP6
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 ZMAT2 Homo sapiens Q96NC0
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 ZMAT2 Homo sapiens Q96NC0
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 ARMCX1 Homo sapiens Q9P291
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 ARMCX1 Homo sapiens Q9P291
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 ZBTB49 Homo sapiens Q6ZSB9
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 ZNF408 Homo sapiens Q9H9D4
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 PIAS2 Homo sapiens O75928
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 DDX6 Homo sapiens P26196
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 PSMC1 Homo sapiens P62191
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 PSMC1 Homo sapiens P62191
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 PSMC1 Homo sapiens P62191
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 BYSL Homo sapiens Q13895
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 BYSL Homo sapiens Q13895
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 BYSL Homo sapiens Q13895
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 BYSL Homo sapiens Q13895
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 RPL9 Homo sapiens P32969
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 RPL9 Homo sapiens P32969
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 CDKL3 Homo sapiens Q8IVW4
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 AP1M1 Homo sapiens Q9BXS5
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 MRPL11 Homo sapiens Q9Y3B7
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 GPATCH2L Homo sapiens Q9NWQ4
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 GPATCH2L Homo sapiens Q9NWQ4
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 GPATCH2L Homo sapiens Q9NWQ4
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 ZCCHC10 Homo sapiens Q8TBK6
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 ZNF587 Homo sapiens Q96SQ5
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 ZNF587 Homo sapiens Q96SQ5
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 FAM161A Homo sapiens Q3B820
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 HIC2 Homo sapiens Q96JB3
Complementation
32296183
Intra
ZBTB8A Q96BR9 HIC2 Homo sapiens Q96JB3
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 ZNF417 Homo sapiens Q8TAU3
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 NTAQ1 Homo sapiens Q96HA8
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 ZBTB24 Homo sapiens O43167
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 ZBTB24 Homo sapiens O43167
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 ZBTB48 Homo sapiens P10074
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 RAD23A Homo sapiens P54725
Validated Y2H
25416956
Intra
ZBTB8A Q96BR9 EIF1AD Homo sapiens Q8N9N8
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 ZNF276 Homo sapiens Q8N554
Y2H Prey Pooling
25416956
Intra
ZBTB8A Q96BR9 ZNF276 Homo sapiens Q8N554
Y2H Array
25416956
Intra
ZBTB8A Q96BR9 KIF9 Homo sapiens Q9HAQ2
Validated Y2H
32296183
Intra
ZBTB8A Q96BR9 AEN Homo sapiens Q8WTP8
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15979 ZBTB7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19274 Zbtb7a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25763 Zbtb7a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown