ZBTB49 - zinc finger and BTB domain containing 49 Gene

Also Known as ZNF509

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 166793

Summary

Enables DNA-binding transcription factor binding activity; sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; and regulation of cell cycle. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in testis (RPKM 3.0), spleen (RPKM 2.4) and 25 other tissues.

ZBTB49 Products (2)

mRNA Protein Name
NM_001330625.2 NP_001317554.1 zinc finger and BTB domain-containing protein 49
NM_145291.4 NP_660334.3 zinc finger and BTB domain-containing protein 49

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IDA
IDA: Inferred from direct assay
25245946 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
25245946 GOA
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
25245946 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
25245946 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
25245946 GOA
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
25245946 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25245946 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25245946 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB49 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZBTB49 Q6ZSB9 GOPC Homo sapiens Q9HD26-2
Y2H Prey Pooling
32296183
Intra
ZBTB49 Q6ZSB9 GOPC Homo sapiens Q9HD26-2
Validated Y2H
32296183
Intra
ZBTB49 Q6ZSB9 GOPC Homo sapiens Q9HD26-2
Y2H Array
32296183
Intra
ZBTB49 Q6ZSB9 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra
ZBTB49 Q6ZSB9 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra
ZBTB49 Q6ZSB9 ZBTB2 Homo sapiens Q8N680
Validated Y2H
32296183
Intra
ZBTB49 Q6ZSB9 ZBTB2 Homo sapiens Q8N680
Y2H Array
32296183
Intra
ZBTB49 Q6ZSB9 ZBTB2 Homo sapiens Q8N680
Y2H Prey Pooling
32296183
Intra
ZBTB49 Q6ZSB9 GOPC Homo sapiens Q9HD26
Y2H Prey Pooling
25416956
Intra
ZBTB49 Q6ZSB9 GOPC Homo sapiens Q9HD26
Y2H Array
25416956
Intra
ZBTB49 Q6ZSB9 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
ZBTB49 Q6ZSB9 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
ZBTB49 Q6ZSB9 TRAF3 Homo sapiens Q13114
Y2H Prey Pooling
32296183
Intra
ZBTB49 Q6ZSB9 TRAF3 Homo sapiens Q13114
Y2H Array
32296183
Intra
ZBTB49 Q6ZSB9 CIB1 Homo sapiens Q99828
Y2H Prey Pooling
32296183
Intra
ZBTB49 Q6ZSB9 CIB1 Homo sapiens Q99828
Validated Y2H
32296183
Intra
ZBTB49 Q6ZSB9 CIB1 Homo sapiens Q99828
Y2H Array
32296183
Intra
ZBTB49 Q6ZSB9 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
ZBTB49 Q6ZSB9 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
ZBTB49 Q6ZSB9 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
ZBTB49 Q6ZSB9 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra
ZBTB49 Q6ZSB9 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
25416956
Intra
ZBTB49 Q6ZSB9 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
32296183
Intra
ZBTB49 Q6ZSB9 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
32296183
Intra
ZBTB49 Q6ZSB9 ZBTB8A Homo sapiens Q96BR9
Y2H Array
25416956
Intra
ZBTB49 Q6ZSB9 ZBTB8A Homo sapiens Q96BR9
Y2H Array
32296183
Intra
ZBTB49 Q6ZSB9 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
ZBTB49 Q6ZSB9 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
ZBTB49 Q6ZSB9 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
ZBTB49 Q6ZSB9 ATP1A3 Homo sapiens P13637
Validated Y2H
32814053
Intra
ZBTB49 Q6ZSB9 ATP1A3 Homo sapiens P13637
Y2H Array
32814053
Intra
ZBTB49 Q6ZSB9 ATP1A3 Homo sapiens P13637
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15974 ZBTB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15975 ZBTB40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15976 ZBTB43 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15977 ZBTB46 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15978 ZBTB48 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15982 ZBTB9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20521 Zbtb9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27030 Zbtb9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown