CIB1 - calcium and integrin binding 1 Gene

Also Known as CIB; CIBP; KIP1; PRKDCIP; SIP2-28

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10519

About CIB1

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,229,975-90,265,759 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in colon (RPKM 49.7), adrenal (RPKM 37.7) and 25 other tissues.

Summary

This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many Other proteins, including the platelet Integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including Cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

CIB1 Products (2)

mRNA	Protein	Name
NM_001277764.2	NP_001264693.1	calcium and integrin-binding protein 1 isoform a
NM_006384.4	NP_006375.2	calcium and integrin-binding protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	15475008	GOA
enables calcium-dependent protein kinase inhibitor activity	IMP IMP: Inferred from mutant phenotype	20473878	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10366599	GOA
enables protein serine/threonine kinase inhibitor activity	IDA IDA: Inferred from direct assay	20473878	GOA
enables protein-membrane adaptor activity	IGI IGI: Inferred from genetic interaction	20639889	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	11756406	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	12011095	GOA
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	10366599	GOA
involved in cellular response to nerve growth factor stimulus	IDA IDA: Inferred from direct assay	21215777	GOA
involved in cellular response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	19854831	GOA
involved in cytoplasmic microtubule organization	IMP IMP: Inferred from mutant phenotype	20951827	GOA
involved in endomitotic cell cycle	IDA IDA: Inferred from direct assay	21264284	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19854831	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21264284	GOA
involved in negative regulation of microtubule depolymerization	IDA IDA: Inferred from direct assay	21215777	GOA
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	21215777	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	19854831	GOA
involved in positive regulation of calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	20639889	GOA
involved in positive regulation of cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	11756406	GOA
involved in positive regulation of protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	20639889	GOA
involved in positive regulation of protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	19854831	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	11756406	GOA
involved in regulation of cell division	IMP IMP: Inferred from mutant phenotype	20951827	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20951827	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell periphery	IDA IDA: Inferred from direct assay	11756406	GOA
located in centrosome	IDA IDA: Inferred from direct assay	20951827	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11756406	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	10366599	GOA
located in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	10366599	GOA
located in filopodium tip	IDA IDA: Inferred from direct assay	20951827	GOA
located in growth cone	IDA IDA: Inferred from direct assay	21215777	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	21215777	GOA
located in membrane	IDA IDA: Inferred from direct assay	10366599	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	21215777	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	21215777	GOA
located in nucleoplasm	IMP IMP: Inferred from mutant phenotype	10366599	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11756406	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11756406	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19854831	GOA
located in sarcolemma	IDA IDA: Inferred from direct assay	20639889	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIB1 Protein Structure

EF-hand_7

0
100
191 a.a.

Protein Preferred Names	Protein Names
calcium and integrin-binding protein 1	DNA-PK interaction protein

CIB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CIB1	Q99828	SCAF1	Homo sapiens	Q9H7N4	Validated Y2H	32296183
Intra	CIB1	Q99828	MAP3K5	Homo sapiens	Q99683	Pull Down	19805025
Intra	CIB1	Q99828	MAP3K5	Homo sapiens	Q99683	Anti Tag CoIP	19805025
Intra	CIB1	Q99828	MAP3K5	Homo sapiens	Q99683	Y2H	19805025
Intra	CIB1	Q99828	STMN2	Homo sapiens	Q93045	Pull Down	21215777
Intra	CIB1	Q99828	STMN2	Homo sapiens	Q93045	PLA	21215777
Intra	CIB1	Q99828	STMN2	Homo sapiens	Q93045	Y2H	21215777
Intra	CIB1	Q99828	STMN2	Homo sapiens	Q93045	Confocal	21215777
Intra	CIB1	Q99828	WASL	Homo sapiens	O00401	Anti Bait CoIP	16582881
Intra	CIB1	Q99828	WASL	Homo sapiens	O00401	SPR	16582881
Intra	CIB1	Q99828	WASL	Homo sapiens	O00401	Anti Tag CoIP	16582881
Intra	CIB1	Q99828	WASL	Homo sapiens	O00401	Y2H	16582881

Cross: Cross-species interaction Intra: Intraspecies interaction

CIB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85102	CIB1 Antibody (YA4794)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Epidermodysplasia Verruciformis 3	Epidermodysplasia Verruciformis, Susceptibility To, 3 EV3
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev
Pityriasis Versicolor	Tinea Versicolor Infection By Pityrosporum Furfur
Usher Syndrome, Type Ij	Usher Syndrome Type 1j USH1J Usher Syndrome Type Ij Usher Syndrome 1j Usher'S Syndrome Type 1j
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Schneiderian Carcinoma	Cylindrical Cell Carcinoma
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162558	NCGC00351170	Inhibitor	99.05%	Unkown
HY-RS02706	CIB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19584	Cib1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26081	Cib1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CIB1	VGNC	VGNC:71189
Mus musculus	CIB1	MGD	MGI:1344418
Felis catus	CIB1	VGNC	VGNC:60898
Canis familiaris	CIB1	VGNC	VGNC:39266
Bos taurus	CIB1	VGNC	VGNC:27359
Rattus norvegicus	CIB1	RGD	RGD:620133
Others	CIB1	NCBI