STMN2 - stathmin 2 Gene

Also Known as SCG10; SCGN10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11075

About STMN2

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:79,611,117-79,666,158 (from NCBI)

This gene has 3 transcripts (splice variants), 284 orthologues and 4 paralogues. Biased expression in brain (RPKM 155.5) and adrenal (RPKM 33.4).

Summary

This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]

STMN2 Products (2)

mRNA	Protein	Name
NM_001199214.2	NP_001186143.1	stathmin-2 isoform 1
NM_007029.4	NP_008960.2	stathmin-2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	21215777	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to nerve growth factor stimulus	IDA IDA: Inferred from direct assay	21215777	GOA
involved in negative regulation of microtubule depolymerization	IDA IDA: Inferred from direct assay	18452648	GOA
involved in negative regulation of microtubule polymerization	IDA IDA: Inferred from direct assay	18452648	GOA
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	18452648	GOA
involved in positive regulation of microtubule depolymerization	IDA IDA: Inferred from direct assay	18452648	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	18452648	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21215777	GOA
located in growth cone	IDA IDA: Inferred from direct assay	21215777	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	21215777	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	21215777	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	21215777	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18452648	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STMN2 Protein Structure

Stathmin

0
100
179 a.a.

Protein Preferred Names	Protein Names
stathmin-2	neuron-specific growth-associated protein

STMN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STMN2	Q93045	TEX11	Homo sapiens	Q8IYF3-3	Y2H Prey Pooling	32296183
Intra	STMN2	Q93045	TEX11	Homo sapiens	Q8IYF3-3	Y2H Array	32296183
Intra	STMN2	Q93045	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	STMN2	Q93045	MBD3	Homo sapiens	O95983-2	Y2H Array	32296183
Intra	STMN2	Q93045	TXLNA	Homo sapiens	P40222	Y2H Array	25416956
Intra	STMN2	Q93045	TXLNA	Homo sapiens	P40222	Y2H Array	31515488
Intra	STMN2	Q93045	TXLNA	Homo sapiens	P40222	Y2H Prey Pooling	25416956
Intra	STMN2	Q93045	TXLNA	Homo sapiens	P40222	Validated Y2H	25416956
Intra	STMN2	Q93045	CIB1	Homo sapiens	Q99828	PLA	21215777
Intra	STMN2	Q93045	CIB1	Homo sapiens	Q99828	Anti Tag CoIP	21215777
Intra	STMN2	Q93045	SESTD1	Homo sapiens	Q86VW0	Y2H Prey Pooling	32296183
Intra	STMN2	Q93045	SESTD1	Homo sapiens	Q86VW0	Y2H Array	32296183
Intra	STMN2	Q93045	TFCP2	Homo sapiens	Q12800	Validated Y2H	25416956
Intra	STMN2	Q93045	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	25416956
Intra	STMN2	Q93045	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	STMN2	Q93045	TEX11	Homo sapiens	Q8IYF3	Pull Down	16189514
Intra	STMN2	Q93045	TEX11	Homo sapiens	Q8IYF3	Validated Y2H	25416956
Intra	STMN2	Q93045	TEX11	Homo sapiens	Q8IYF3	Y2H Array	25416956
Intra	STMN2	Q93045	TEX11	Homo sapiens	Q8IYF3	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Trichorhinophalangeal Syndrome, Type Ii	Langer-Giedion Syndrome Lgs Trichorhinophalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome Type 2 TRPS2 Monosomy 8q24.1 Chromosome 8q24.1 Deletion Syndrome Deletion 8q24.1 Giedion-Langer Syndrome Trichorhinophalangeal Dysplasia Type Ii Langer Giedion Syndrome Trps 2 Tricho-Rhino-Phalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome With Exostosis Trps Ii Tricho-Rhino-Phalangeal Syndrome 2 8q24.1 Microdeletion Syndrome 8q24.1 Deletion Syndrome
Creutzfeldt-Jakob Disease	Variant Creutzfeldt-Jakob Disease CJD Bovine Spongiform Encephalopathy Vcjd Inherited Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Familial Creutzfeldt Jakob Disease Creutzfeldt-Jacob Disease Creutzfeldt Jacob Disease Sporadic Creutzfeldt-Jakob Disease Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Disease, Variant, Resistance To Creutzfeldt-Jakob Disease, Variant Creutzfeldt Jacob Syndrome Jakob-Creutzfeldt Disease Subacute Spongiform Encephalopathy Transmissible Virus Dementia New Variant Of Cjd Nv-Cjd Variant Cjd Variant Creutzfeldt-Jacob Disease Sporadic Cjd Inherited Cjd Acquired Creutzfeldt-Jakob Disease Variant Mcj Encephalopathy Bovine Spongiform Familial Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome New Variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Sporadic Acquired Cjd Scjd - [Sporadic Creutzfeldt-Jakob Disease] Idiopathic Creutzfeldt-Jakob Disease Creutzfeld-Jakob Disease Nos Vcjd - [Variant Creutzfeldt-Jakob Disease]
Kuru	Kuru, Susceptibility To Kuru Encephalopathy Kuru Encephalitis Kuru Disease
Budd-Chiari Syndrome	Hepatic Vein Thrombosis Chiari Syndrome BDCHS Membranous Obstruction Of The Inferior Vena Cava Budd-Chiari Syndrome, Somatic Movc Budd-Chiari Syndrome, Susceptibility To, Somatic Budd-Chiari Syndrome, Susceptibility To Membranous Obstruction Of Inferior Vena Cava Hepatic Vein Block Obstruction Of Hepatic Veins Hepatic Vein Obstruction Hepatic Venous Block
Chromosome 8q21.11 Deletion Syndrome	8q21.11 Microdeletion Syndrome Del(8)(Q21.11) Deletion 8q21.11 Monosomy 8q21.11
Goldberg-Shprintzen Syndrome	Goldberg-Shprintzen Megacolon Syndrome GOSHS Megacolon-Microcephaly Syndrome
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13944	STMN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21771	Stmn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28288	Stmn2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STMN2	MGD	MGI:98241
Rattus norvegicus	STMN2	RGD	RGD:68947
Canis familiaris	STMN2	VGNC	VGNC:46926
Felis catus	STMN2	VGNC	VGNC:81677
Bos taurus	STMN2	VGNC	VGNC:35404
Macaca mulatta	STMN2	VGNC	VGNC:78038
Others	STMN2	NCBI