ZBTB2 - zinc finger and BTB domain containing 2 Gene

Also Known as ZNF437

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57621

About ZBTB2

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:151,364,115-151,391,559 (from NCBI)

This gene has 1 transcript (splice variant) and 210 orthologues. Ubiquitous expression in thyroid (RPKM 17.1), lymph node (RPKM 6.4) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB2 Products (1)

mRNA Protein Name
NM_020861.3 NP_065912.1 zinc finger and BTB domain-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19380588 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
25609694 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25609694 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19380588 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB2 Protein Structure

BTB

BTB: BTB/POZ domain (14 - 103)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (254 - 276)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (378 - 399)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (448 - 466)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 2

ZBTB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZBTB2 Q8N680 MKLN1 Homo sapiens Q9UL63
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 RASSF8 Homo sapiens Q8NHQ8-2
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
ZBTB2 Q8N680 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
ZBTB2 Q8N680 ZNF639 Homo sapiens Q9UID6
Y2H Prey Pooling
32296183
Intra
ZBTB2 Q8N680 ZNF639 Homo sapiens Q9UID6
Anti Tag CoIP
33961781
Intra
ZBTB2 Q8N680 SP1 Homo sapiens P08047
Anti Bait CoIP
25609694
Intra
ZBTB2 Q8N680 ZNF639 Homo sapiens Q9UID6
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 ZBTB25 Homo sapiens P24278
Anti Tag CoIP
33961781
Intra
ZBTB2 Q8N680 ZNF639 Homo sapiens Q9UID6
Y2H Array
32296183
Intra
ZBTB2 Q8N680 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
Intra
ZBTB2 Q8N680 LHX4 Homo sapiens Q969G2
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
Intra
ZBTB2 Q8N680 ZBTB18 Homo sapiens Q99592
Y2H Prey Pooling
32296183
Intra
ZBTB2 Q8N680 ZBTB18 Homo sapiens Q99592
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 ZBTB18 Homo sapiens Q99592
Y2H Array
32296183
Intra
ZBTB2 Q8N680 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 MRPL11 Homo sapiens Q9Y3B7
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 ZMYND19 Homo sapiens Q96E35
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 IP6K2 Homo sapiens Q9UHH9
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 TENT5B Homo sapiens Q96A09
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 DAXX Homo sapiens Q9UER7
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
ZBTB2 Q8N680 TMC6 Homo sapiens Q7Z403
Y2H Array
32296183
Intra
ZBTB2 Q8N680 TMC6 Homo sapiens Q7Z403
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 10

  • RP10

  • Retinitis Pigmentosa-10

  • Retinitis Pigmentosa, Type 10
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15967 ZBTB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19758 Zbtb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26255 Zbtb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ZBTB2 VGNC VGNC:37064
Canis familiaris ZBTB2 VGNC VGNC:54005
Felis catus ZBTB2 VGNC VGNC:102550
Mus musculus ZBTB2 MGD MGI:2685949
Rattus norvegicus ZBTB2 RGD RGD:1306621
Macaca mulatta ZBTB2 VGNC VGNC:79291
Others ZBTB2 NCBI