ZBTB25 - zinc finger and BTB domain containing 25 Gene
Also Known as KUP; ZNF46; C14orf51
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 7597
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in liver (RPKM 4.4), thyroid (RPKM 2.4) and 25 other tissues.
ZBTB25 Products (9)
| mRNA | Protein | Name |
|---|---|---|
| NM_001304507.1 | NP_001291436.1 | zinc finger and BTB domain-containing protein 25 isoform a |
| NM_001304508.1 | NP_001291437.1 | zinc finger and BTB domain-containing protein 25 isoform b |
| NM_001354682.2 | NP_001341611.1 | zinc finger and BTB domain-containing protein 25 isoform c |
| NM_001354683.2 | NP_001341612.1 | zinc finger and BTB domain-containing protein 25 isoform d |
| NM_001354684.2 | NP_001341613.1 | zinc finger and BTB domain-containing protein 25 isoform a |
| NM_001354685.2 | NP_001341614.1 | zinc finger and BTB domain-containing protein 25 isoform a |
| NM_001354686.2 | NP_001341615.1 | zinc finger and BTB domain-containing protein 25 isoform a |
| NM_001354687.2 | NP_001341616.1 | zinc finger and BTB domain-containing protein 25 isoform a |
| NM_006977.5 | NP_008908.2 | zinc finger and BTB domain-containing protein 25 isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
ZBTB25 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ZBTB25 | P24278 | PNMA5 | Homo sapiens | Q96PV4 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | PNMA5 | Homo sapiens | Q96PV4 | 31515488 | |
|
Intra
|
ZBTB25 | P24278 | PNMA5 | Homo sapiens | Q96PV4 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | PNMA5 | Homo sapiens | Q96PV4 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | DDIT3 | Homo sapiens | P35638-2 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
ZBTB25 | P24278 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
ZBTB25 | P24278 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
ZBTB25 | P24278 | CRACR2B | Homo sapiens | Q8N4Y2-3 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | CRACR2B | Homo sapiens | Q8N4Y2-3 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | CRACR2B | Homo sapiens | Q8N4Y2-3 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | KRTAP17-1 | Homo sapiens | Q9BYP8 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | KRTAP17-1 | Homo sapiens | Q9BYP8 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | KRTAP17-1 | Homo sapiens | Q9BYP8 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | ZBTB2 | Homo sapiens | Q8N680 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | ZBTB2 | Homo sapiens | Q8N680 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | ZBTB2 | Homo sapiens | Q8N680 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | ZBTB1 | Homo sapiens | Q9Y2K1 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | ZBTB1 | Homo sapiens | Q9Y2K1 | 20211142 | |
|
Intra
|
ZBTB25 | P24278 | ZBTB1 | Homo sapiens | Q9Y2K1 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | ZBTB1 | Homo sapiens | Q9Y2K1 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | VMAC | Homo sapiens | Q2NL98 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | VMAC | Homo sapiens | Q2NL98 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | VMAC | Homo sapiens | Q2NL98 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | VCP | Homo sapiens | P55072 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | VCP | Homo sapiens | P55072 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | VCP | Homo sapiens | P55072 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | TRAF2 | Homo sapiens | Q12933 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | TRAF2 | Homo sapiens | Q12933 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | TNIP1 | Homo sapiens | Q15025 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | TNIP1 | Homo sapiens | Q15025 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | TNIP1 | Homo sapiens | Q15025 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | TNIP1 | Homo sapiens | Q15025 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | TNIP1 | Homo sapiens | Q15025 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | APIP | Homo sapiens | Q96GX9 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | APIP | Homo sapiens | Q96GX9 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | APIP | Homo sapiens | Q96GX9 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | TRAF6 | Homo sapiens | Q9Y4K3 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | TRAF6 | Homo sapiens | Q9Y4K3 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | TRAF6 | Homo sapiens | Q9Y4K3 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | TARDBP | Homo sapiens | Q13148 | 32814053 | |
|
Intra
|
ZBTB25 | P24278 | TARDBP | Homo sapiens | Q13148 | 32814053 | |
|
Intra
|
ZBTB25 | P24278 | TARDBP | Homo sapiens | Q13148 | 32814053 | |
|
Intra
|
ZBTB25 | P24278 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | KCTD9 | Homo sapiens | Q7L273 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | KCTD9 | Homo sapiens | Q7L273 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | KCTD9 | Homo sapiens | Q7L273 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | HTRA2 | Homo sapiens | O43464 | 32814053 | |
|
Intra
|
ZBTB25 | P24278 | HTRA2 | Homo sapiens | O43464 | 32814053 | |
|
Intra
|
ZBTB25 | P24278 | HTRA2 | Homo sapiens | O43464 | 32814053 | |
|
Intra
|
ZBTB25 | P24278 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
ZBTB25 | P24278 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
ZBTB25 | P24278 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
ZBTB25 | P24278 | SEPHS1 | Homo sapiens | P49903 | 21516116 | |
|
Intra
|
ZBTB25 | P24278 | SEPHS1 | Homo sapiens | P49903 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | SEPHS1 | Homo sapiens | P49903 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | SEPHS1 | Homo sapiens | P49903 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | SEPHS1 | Homo sapiens | P49903 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | TBC1D5 | Homo sapiens | Q92609 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | TBC1D5 | Homo sapiens | Q92609 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | TBC1D5 | Homo sapiens | Q92609 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | HSBP1 | Homo sapiens | O75506 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | HSBP1 | Homo sapiens | O75506 | 32296183 | |
|
Intra
|
ZBTB25 | P24278 | KCTD1 | Homo sapiens | Q719H9 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | KCTD1 | Homo sapiens | Q719H9 | 25416956 | |
|
Intra
|
ZBTB25 | P24278 | KCTD1 | Homo sapiens | Q719H9 | 25416956 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(5)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS15968 | ZBTB20 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS15967 | ZBTB2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS15969 | ZBTB24 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS19758 | Zbtb2 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS26255 | Zbtb2 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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