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APIP - APAF1 interacting protein Gene

Also Known as APIP2; CGI29; hAPIP; CGI-29; MMRP19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51074

About APIP

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,882,295-34,916,379 (from NCBI)

This gene has 3 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in fat (RPKM 15.7), adrenal (RPKM 13.7) and 25 other tissues.

Summary

APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]

APIP Products (1)

mRNA	Protein	Name
NM_015957.4	NP_057041.2	methylthioribulose-1-phosphate dehydratase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables methylthioribulose 1-phosphate dehydratase activity	IDA IDA: Inferred from direct assay	24367089	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	24367089	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in L-methionine salvage from methylthioadenosine	IMP IMP: Inferred from mutant phenotype	22837397	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22837397	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	24367089	GOA
involved in pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	24367089	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23285211	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APIP Protein Structure

Aldolase_II

0
100
200
242 a.a.

Protein Preferred Names	Protein Names
methylthioribulose-1-phosphate dehydratase	MTRu-1-P dehydratase

APIP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	APIP	Q96GX9	PDZD4	Homo sapiens	Q17RL8	Y2H Array	31515488
Intra	APIP	Q96GX9	PDZD4	Homo sapiens	Q17RL8	Validated Y2H	25416956
Intra	APIP	Q96GX9	SKP1	Homo sapiens	P63208	Y2H Prey Pooling	25416956
Intra	APIP	Q96GX9	SKP1	Homo sapiens	P63208	Y2H Array	25416956
Intra	APIP	Q96GX9	IMPDH2	Homo sapiens	P12268	Y2H Array	25416956
Intra	APIP	Q96GX9	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	APIP	Q96GX9	APIP	Homo sapiens	Q96GX9	Y2H Pooling	16189514
Intra	APIP	Q96GX9	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	APIP	Q96GX9	APIP	Homo sapiens	Q96GX9	Pull Down	16189514
Intra	APIP	Q96GX9	APIP	Homo sapiens	Q96GX9	Y2H Array	31515488
Intra	APIP	Q96GX9	APIP	Homo sapiens	Q96GX9	Y2H Prey Pooling	25416956
Intra	APIP	Q96GX9	APIP	Homo sapiens	Q96GX9	Validated Y2H	25416956
Intra	APIP	Q96GX9	APIP	Homo sapiens	Q96GX9	Y2H Prey Pooling	32296183
Intra	APIP	Q96GX9	APIP	Homo sapiens	Q96GX9	Y2H Array	19060904
Intra	APIP	Q96GX9	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
Intra	APIP	Q96GX9	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	APIP	Q96GX9	NUDT18	Homo sapiens	Q6ZVK8	Y2H Pooling	16189514
Intra	APIP	Q96GX9	APIP	Homo sapiens	Q96GX9	Validated Y2H	32296183
Intra	APIP	Q96GX9	APIP	Homo sapiens	Q96GX9	Y2H Array	25416956
Intra	APIP	Q96GX9	APIP	Homo sapiens	Q96GX9	Y2H Pooling	19060904
Intra	APIP	Q96GX9	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	APIP	Q96GX9	APIP	Homo sapiens	Q96GX9	Y2H Array	32296183
Intra	APIP	Q96GX9	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	25416956
Intra	APIP	Q96GX9	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	APIP	Q96GX9	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	APIP	Q96GX9	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	APIP	Q96GX9	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	APIP	Q96GX9	TNPO2	Homo sapiens	O14787	Y2H Prey Pooling	25416956
Intra	APIP	Q96GX9	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	APIP	Q96GX9	TSC22D4	Homo sapiens	Q9Y3Q8	Validated Y2H	25416956
Intra	APIP	Q96GX9	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Array	25416956
Intra	APIP	Q96GX9	TSC22D4	Homo sapiens	Q9Y3Q8	Y2H Prey Pooling	25416956
Intra	APIP	Q96GX9	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
Intra	APIP	Q96GX9	CFAP206	Homo sapiens	Q8IYR0	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Endocervicitis
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00820	APIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20249	Apip Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26757	Apip Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	APIP	VGNC	VGNC:99543
Mus musculus	APIP	MGD	MGI:1926788
Felis catus	APIP	VGNC	VGNC:59850
Bos taurus	APIP	VGNC	VGNC:26016
Canis familiaris	APIP	VGNC	VGNC:37986
Rattus norvegicus	APIP	RGD	RGD:1564562
Others	APIP	NCBI