IMPDH2 - inosine monophosphate dehydrogenase 2 Gene

Also Known as IMPD2; IMPDH-II

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3615

About IMPDH2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,024,325-49,029,398 (from NCBI)

This gene has 36 transcripts (splice variants), 202 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 136.8), skin (RPKM 49.4) and 25 other tissues.

Summary

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

IMPDH2 Products (4)

mRNA Protein Name
NM_000884.3 NP_000875.2 inosine-5'-monophosphate dehydrogenase 2 isoform 2
NM_001410759.1 NP_001397688.1 inosine-5'-monophosphate dehydrogenase 2 isoform 1
NM_001410760.1 NP_001397689.1 inosine-5'-monophosphate dehydrogenase 2 isoform 3
NM_001410761.1 NP_001397690.1 inosine-5'-monophosphate dehydrogenase 2 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables IMP dehydrogenase activity IDA
IDA: Inferred from direct assay
7903306 GOA
enables nucleotide binding IDA
IDA: Inferred from direct assay
14766016 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in GTP biosynthetic process IDA
IDA: Inferred from direct assay
7903306 GOA
involved in circadian rhythm IDA
IDA: Inferred from direct assay
28985504 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14766016 GOA
located in cytosol IDA
IDA: Inferred from direct assay
31337707 GOA
located in nucleus IDA
IDA: Inferred from direct assay
14766016 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IMPDH2 Protein Structure

IMPDH

IMPDH: IMP dehydrogenase / GMP reductase domain (29 - 504)

CBS

CBS: CBS domain (116 - 163)

CBS

CBS: CBS domain (176 - 229)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
Protein Preferred Names Protein Names

inosine-5'-monophosphate dehydrogenase 2

  • IMP (inosine 5'-monophosphate) dehydrogenase 2

IMPDH2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IMPDH2 P12268 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
IMPDH2 P12268 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
IMPDH2 P12268 POU6F2 Homo sapiens P78424
Validated Y2H
32296183
Intra
IMPDH2 P12268 IMPDH1 Homo sapiens P20839-3
Y2H Prey Pooling
32296183
Intra
IMPDH2 P12268 IMPDH1 Homo sapiens P20839-3
Validated Y2H
32296183
Intra
IMPDH2 P12268 IMPDH1 Homo sapiens P20839-3
Y2H Array
32296183
Intra
IMPDH2 P12268 IL1F10 Homo sapiens Q8WWZ1
Y2H Prey Pooling
32296183
Intra
IMPDH2 P12268 IL1F10 Homo sapiens Q8WWZ1
Validated Y2H
32296183
Intra
IMPDH2 P12268 IL1F10 Homo sapiens Q8WWZ1
Y2H Array
32296183
Intra
IMPDH2 P12268 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra
IMPDH2 P12268 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
IMPDH2 P12268 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
IMPDH2 P12268 APIP Homo sapiens Q96GX9
Y2H Prey Pooling
25416956
Intra
IMPDH2 P12268 APIP Homo sapiens Q96GX9
Validated Y2H
25416956
Intra
IMPDH2 P12268 STAT3 Homo sapiens P40763
Validated Y2H
32296183
Intra
IMPDH2 P12268 STAT3 Homo sapiens P40763
Y2H Prey Pooling
32296183
Intra
IMPDH2 P12268 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra
IMPDH2 P12268 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra
IMPDH2 P12268 CPLANE2 Homo sapiens Q9BU20
Y2H Prey Pooling
25416956
Intra
IMPDH2 P12268 CPLANE2 Homo sapiens Q9BU20
Validated Y2H
32296183
Intra
IMPDH2 P12268 CPLANE2 Homo sapiens Q9BU20
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

IMPDH2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82346 IMPDH2 Antibody (YA2091) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Impdh2 Enzyme Activity, Variation In

  • IMPDH2V

  • Activity, Enzyme, Impdh2, Variation In
Gtp Cyclohydrolase 1-Deficient Dopa-Responsive Dystonia

  • Autosomal Dominant Dopa-Responsive Dystonia

  • Autosomal Dominant Segawa Syndrome

  • Dyt5a

  • Hereditary Progressive Dystonia With Marked Diurnal Fluctuation

  • Gtpch1-Deficient Drd

  • Gtpch1-Deficient Dopa-Responsive Dystonia

  • Dopa-Responsive Dystonia, With Or Without Hyperphenylalaninemia

  • Dyt-Gch1

  • Dyt/Park-Gch1

  • Dopa-Responsive Dystonia Autosomal Dominant Segawa Syndrome

  • Hpd With Marked Diurnal Fluctuation

  • Dopa-Responsive Dystonia
Dystonia

  • Dystonic Disease

  • Dystonic Disorder

  • Dystonia Disorders

  • Neuroleptic Dyskinesia
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-174221 IMPDH II/HDAC1-IN-1 Inhibitor / Unkown
HY-169296 IMPDH2-IN-4 Inhibitor / Unkown
HY-147342 β-Benzamide adenine dinucleotide Inhibitor / Unkown
HY-118917 VX-148 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus IMPDH2 VGNC VGNC:67798
Canis familiaris IMPDH2 VGNC VGNC:42011
Rattus norvegicus IMPDH2 RGD RGD:735092
Macaca mulatta IMPDH2 VGNC VGNC:73740
Bos taurus IMPDH2 VGNC VGNC:30189
Mus musculus IMPDH2 MGD MGI:109367
Others IMPDH2 NCBI