NUDT18 - nudix hydrolase 18 Gene

Also Known as MTH3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79873

Summary

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of Guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]
Ubiquitous expression in spleen (RPKM 3.1), lymph node (RPKM 2.8) and 25 other tissues.

NUDT18 Products (1)

mRNA Protein Name
NG_032941.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 8-hydroxy-dADP phosphatase activity EXP
EXP: Inferred from Experiment
22556419 GOA
enables 8-hydroxy-dADP phosphatase activity IDA
IDA: Inferred from direct assay
22556419 GOA
enables 8-oxo-GDP phosphatase activity EXP
EXP: Inferred from Experiment
22556419 GOA
enables 8-oxo-GDP phosphatase activity IDA
IDA: Inferred from direct assay
22556419 GOA
enables 8-oxo-dGDP phosphatase activity EXP
EXP: Inferred from Experiment
22556419 GOA
enables 8-oxo-dGDP phosphatase activity IDA
IDA: Inferred from direct assay
22556419 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in GDP catabolic process IDA
IDA: Inferred from direct assay
22556419 GOA
involved in dADP catabolic process IDA
IDA: Inferred from direct assay
22556419 GOA
involved in dGDP catabolic process IDA
IDA: Inferred from direct assay
22556419 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT18 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NUDT18 Q6ZVK8 DUT Homo sapiens P33316
Y2H Array
19060904
Intra
NUDT18 Q6ZVK8 DUT Homo sapiens P33316
Y2H Pooling
19060904
Intra
NUDT18 Q6ZVK8 APIP Homo sapiens Q96GX9
Y2H Array
19060904
Intra
NUDT18 Q6ZVK8 APIP Homo sapiens Q96GX9
Y2H Pooling
19060904
Intra
NUDT18 Q6ZVK8 APIP Homo sapiens Q96GX9
Y2H Array
31515488
Intra
NUDT18 Q6ZVK8 RABAC1 Homo sapiens Q9UI14
Y2H Array
19060904
Intra
NUDT18 Q6ZVK8 RABAC1 Homo sapiens Q9UI14
Y2H Pooling
19060904
Intra
NUDT18 Q6ZVK8 HSD17B14 Homo sapiens Q9BPX1
Y2H Array
19060904
Intra
NUDT18 Q6ZVK8 HSD17B14 Homo sapiens Q9BPX1
Y2H Pooling
19060904
Intra
NUDT18 Q6ZVK8 EVI5L Homo sapiens Q96CN4
Y2H Pooling
16189514
Intra
NUDT18 Q6ZVK8 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
NUDT18 Q6ZVK8 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Cross
NUDT18 Q6ZVK8 tax Human T-cell leukemia virus P03410
Y2H Array
22458338
Cross
NUDT18 Q6ZVK8 tax Human T-cell leukemia virus P03410
Y2H Pooling
22458338
Cross
NUDT18 Q6ZVK8 tax Human T-cell leukemia virus 1 P14079
Y2H Array
22458338
Cross
NUDT18 Q6ZVK8 tax Human T-cell leukemia virus 1 P14079
Y2H Pooling
22458338
Cross: Cross-species interaction Intra: Intraspecies interaction