DUT - deoxyuridine triphosphatase Gene

Also Known as BMFDMS; dUTPase

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1854

About DUT

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:48,331,095-48,343,373 (from NCBI)

This gene has 11 transcripts (splice variants) and 263 orthologues. Ubiquitous expression in bone marrow (RPKM 16.5), lymph node (RPKM 14.4) and 25 other tissues.

Summary

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

DUT Products (4)

mRNA	Protein	Name
NM_001025248.2	NP_001020419.1	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 1 precursor
NM_001025249.1	NP_001020420.1	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 3
NM_001330286.2	NP_001317215.1	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 4
NM_001948.4	NP_001939.1	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dUTP diphosphatase activity	IDA IDA: Inferred from direct assay	8631816	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dTMP biosynthetic process	IDA IDA: Inferred from direct assay	10952785	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in nucleus	IDA IDA: Inferred from direct assay	8631816	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUT Protein Structure

dUTPase

0
100
200
252 a.a.

Protein Preferred Names	Protein Names
deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial	dUTP diphosphatase

DUT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DUT	P33316	NUDT18	Homo sapiens	Q6ZVK8	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DUT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70026	dUTPase/DUT Protein, Human	P33316-2 (M1-N164)	≥ 95%, as determined by reducing SDS-PAGE.

DUT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87153	dUTPase Antibody (YA6846)	WB, IHC-P, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Bone Marrow Failure And Diabetes Mellitus Syndrome	BMFDMS
Cysticercosis	Neurocysticercosis Submacular Cysticercosis Intestinal Taenia Solium Infection Pork Tapeworm Infection Tapeworm Infection: Intestinal Taenia Solum Tapeworm Infection: Pork Tenia Solium Infectious Disease Taeniasis Tenia Solium Infection Cysticerciasis Infection Due To Larval Form Of Taenia Solium

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04071	DUT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W243971	DUT-5		/	Unkown
HY-W243979	DUT-8(Co)		/	Unkown
HY-W249558	DUT-8(Cu)		/	Unkown
HY-W249567	DUT-8(Ni)		/	Unkown
HY-RS20235	Dut Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26742	Dut Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DUT	MGD	MGI:1346051
Rattus norvegicus	DUT	RGD	RGD:620849
Canis familiaris	DUT	VGNC	VGNC:59110
Others	DUT	NCBI